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    Cops2 COP9 signalosome subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 12848, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cops2provided by MGI
    Official Full Name
    COP9 signalosome subunit 2provided by MGI
    Primary source
    MGI:MGI:1330276
    See related
    Ensembl:ENSMUSG00000027206 AllianceGenome:MGI:1330276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csn2; Sgn2; Trip15; TRIP-15
    Summary
    Enables transcription corepressor activity. Acts upstream of or within blastocyst growth; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 25.1), CNS E11.5 (RPKM 23.9) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cops2 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125672222..125701002, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125830302..125859082, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SHC (Src homology 2 domain containing) family, member 4 Neighboring gene STARR-seq mESC enhancer starr_05593 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125550365-125550474 Neighboring gene predicted gene, 35231 Neighboring gene STARR-positive B cell enhancer ABC_E11155 Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 2
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 2
    JAB1-containing signalosome subunit 2
    TR-interacting protein 15
    alien homolog
    alien-like
    thyroid receptor-interacting protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285507.1NP_001272436.1  COP9 signalosome complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_001272436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK037757, AL844580, BQ031086, CJ052709
      Consensus CDS
      CCDS71133.1
      UniProtKB/TrEMBL
      Q3UK65, Q3V3N6
      Related
      ENSMUSP00000106090.2, ENSMUST00000110463.8
      Conserved Domains (2) summary
      COG5159
      Location:40441
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:316420
      PCI; PCI domain
    2. NM_001285512.1NP_001272441.1  COP9 signalosome complex subunit 2 isoform c

      See identical proteins and their annotated locations for NP_001272441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK084421, AK132776, BQ031086, CJ052709
      UniProtKB/Swiss-Prot
      P61202
      Conserved Domains (2) summary
      COG5159
      Location:1310
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:185289
      PCI; PCI domain
    3. NM_001285513.1NP_001272442.1  COP9 signalosome complex subunit 2 isoform c

      See identical proteins and their annotated locations for NP_001272442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AL844580
      Conserved Domains (2) summary
      COG5159
      Location:1310
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:185289
      PCI; PCI domain
    4. NM_009939.3NP_034069.2  COP9 signalosome complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_034069.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK084421, BQ031086, CJ052709
      Consensus CDS
      CCDS16679.1
      UniProtKB/Swiss-Prot
      P61202, Q3V1W6, Q8R5B0, Q9CWU1
      UniProtKB/TrEMBL
      Q3UK65
      Related
      ENSMUSP00000028635.6, ENSMUST00000028635.6
      Conserved Domains (2) summary
      COG5159
      Location:40434
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:309413
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125672222..125701002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)