U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 21366, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc6a6provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, taurine), member 6provided by MGI
    Primary source
    MGI:MGI:98488
    See related
    Ensembl:ENSMUSG00000030096 AllianceGenome:MGI:98488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taut
    Summary
    Enables beta-alanine transmembrane transporter activity; gamma-aminobutyric acid:sodium:chloride symporter activity; and taurine:sodium symporter activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within beta-alanine transport and taurine transmembrane transport. Is active in GABA-ergic synapse and postsynaptic membrane. Is expressed in several structures, including brain; cardiovascular system; retina; spinal cord mantle layer; and tooth. Used to study retinitis pigmentosa. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 68.2), kidney adult (RPKM 51.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc6a6 in Genome Data Viewer
    Location:
    6 D1; 6 40.73 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91661031..91736044)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91684048..91759063)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9671 Neighboring gene STARR-seq mESC enhancer starr_16643 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:91629122-91629420 Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628 Neighboring gene STARR-seq mESC enhancer starr_16652 Neighboring gene STARR-seq mESC enhancer starr_16656 Neighboring gene STARR-seq mESC enhancer starr_16660 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene coiled-coil domain containing 174 Neighboring gene STARR-positive B cell enhancer ABC_E6456 Neighboring gene RIKEN cDNA 4930590J08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alanine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-alanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
     
    enables gamma-aminobutyric acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables gamma-aminobutyric acid:sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables taurine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables taurine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taurine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables taurine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables taurine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taurine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in alanine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in alanine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within beta-alanine transport IDA
    Inferred from Direct Assay
    more info
     
    involved_in gamma-aminobutyric acid import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of nitrogen compound transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in taurine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within taurine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within taurine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in taurine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium- and chloride-dependent taurine transporter
    Names
    solute carrier family 6 member 6
    taurine/beta-alanine transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410446.1NP_001397375.1  sodium- and chloride-dependent taurine transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC162914
      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
    2. NM_001410447.1NP_001397376.1  sodium- and chloride-dependent taurine transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC162914
      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
    3. NM_001410448.1NP_001397377.1  sodium- and chloride-dependent taurine transporter isoform b

      Status: VALIDATED

      Source sequence(s)
      AC162914
    4. NM_001410449.1NP_001397378.1  sodium- and chloride-dependent taurine transporter isoform c

      Status: VALIDATED

      Source sequence(s)
      AC162914
    5. NM_001410450.1NP_001397379.1  sodium- and chloride-dependent taurine transporter isoform d

      Status: VALIDATED

      Source sequence(s)
      AC162914
    6. NM_001410451.1NP_001397380.1  sodium- and chloride-dependent taurine transporter isoform e

      Status: VALIDATED

      Source sequence(s)
      AC162914
      UniProtKB/TrEMBL
      Q8BRX2
      Related
      ENSMUST00000206835.2
    7. NM_001410452.1NP_001397381.1  sodium- and chloride-dependent taurine transporter isoform e

      Status: VALIDATED

      Source sequence(s)
      AC162914
      UniProtKB/TrEMBL
      Q8BRX2
    8. NM_009320.5NP_033346.2  sodium- and chloride-dependent taurine transporter isoform a

      See identical proteins and their annotated locations for NP_033346.2

      Status: VALIDATED

      Source sequence(s)
      AC162914
      Consensus CDS
      CCDS39570.1
      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
      Related
      ENSMUSP00000032185.8, ENSMUST00000032185.9
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. NR_177072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162914
    2. NR_177073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162914

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      91661031..91736044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166008.1XP_036021901.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_030255304.2XP_030111164.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_006505870.2XP_006505933.1  sodium- and chloride-dependent taurine transporter isoform X2

      See identical proteins and their annotated locations for XP_006505933.1

      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_036166010.1XP_036021903.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      O35316, P31642, Q91WI2
      UniProtKB/TrEMBL
      Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_003956177.2 RNA Sequence