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    Tha1 threonine aldolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 71776, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tha1provided by MGI
    Official Full Name
    threonine aldolase 1provided by MGI
    Primary source
    MGI:MGI:1919026
    See related
    Ensembl:ENSMUSG00000017713 AllianceGenome:MGI:1919026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLY1; 1300017K07Rik
    Summary
    Predicted to enable L-allo-threonine aldolase activity. Predicted to be involved in glycine biosynthetic process and threonine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human THA1P (threonine aldolase 1, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 19.6), adrenal adult (RPKM 18.8) and 24 other tissues See more
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    Genomic context

    See Tha1 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117758775..117764352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117867949..117873526, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm780 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733294-117733546 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733656-117733839 Neighboring gene transmembrane protein 235 Neighboring gene predicted gene 11725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117774097-117774206 Neighboring gene STARR-seq mESC enhancer starr_31285 Neighboring gene STARR-positive B cell enhancer ABC_E8474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117813554-117813821 Neighboring gene STARR-positive B cell enhancer ABC_E5308 Neighboring gene STARR-seq mESC enhancer starr_31288 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene STARR-positive B cell enhancer ABC_E7103 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene microRNA 6933

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-allo-threonine aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in glycine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027919.5NP_082195.2  threonine aldolase 1

      See identical proteins and their annotated locations for NP_082195.2

      Status: VALIDATED

      Source sequence(s)
      AL591433
      Consensus CDS
      CCDS48993.1
      UniProtKB/TrEMBL
      Q6XPS7
      Related
      ENSMUSP00000033230.8, ENSMUST00000033230.8
      Conserved Domains (1) summary
      cl18945
      Location:40388
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117758775..117764352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534261.3XP_006534324.1  threonine aldolase 1 isoform X1

      Conserved Domains (1) summary
      cl18945
      Location:9264
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...