Efs embryonal Fyn-associated substrate [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efsprovided by MGI
Official Full Name: embryonal Fyn-associated substrateprovided by MGI
Primary source: MGI:MGI:105311
See related: Ensembl:ENSMUSG00000022203 AllianceGenome:MGI:105311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables SH3 domain binding activity. Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 32.5), ovary adult (RPKM 23.9) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 27.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55154087..55164222, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54916543..54926788, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
Title: Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Efs (e-PCR), detects polymorphism
- UniSTS:142971

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: embryonal Fyn-associated substrate

Names: SRC-interacting protein; signal-integrating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424432.1 → NP_001411361.1 embryonal Fyn-associated substrate isoform 2

Status: VALIDATED

Source sequence(s)

CT025533

UniProtKB/TrEMBL

A0A2I3BRP5

Related

ENSMUSP00000154657.2, ENSMUST00000227037.2
NM_001424433.1 → NP_001411362.1 embryonal Fyn-associated substrate isoform 3

Status: VALIDATED

Source sequence(s)

CT025533
NM_001424434.1 → NP_001411363.1 embryonal Fyn-associated substrate isoform 4

Status: VALIDATED

Source sequence(s)

CT025533
NM_010112.5 → NP_034242.2 embryonal Fyn-associated substrate isoform 1

See identical proteins and their annotated locations for NP_034242.2

Status: VALIDATED

Source sequence(s)

CT025533

Consensus CDS

CCDS36925.1

UniProtKB/Swiss-Prot

Q64355, Q8BSX4

UniProtKB/TrEMBL

Q8K0F6

Related

ENSMUSP00000022813.7, ENSMUST00000022813.8

Conserved Domains (2) summary

cd12003
Location:8 → 70

SH3_EFS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Embryonal Fyn-associated Substrate

cl13463
Location:371 → 555

FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module