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    Pdgfa platelet derived growth factor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18590, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pdgfaprovided by MGI
    Official Full Name
    platelet derived growth factor, alphaprovided by MGI
    Primary source
    MGI:MGI:97527
    See related
    Ensembl:ENSMUSG00000025856 AllianceGenome:MGI:97527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PDGF-1
    Summary
    Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development; embryonic lung development; and lung alveolus development. Acts upstream of or within several processes, including hair follicle development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 22.6), colon adult (RPKM 19.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdgfa in Genome Data Viewer
    Location:
    5 G2; 5 77.65 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138961761..138986336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138976014..139000792, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31891 Neighboring gene STARR-seq mESC enhancer starr_14676 Neighboring gene predicted gene, 38726 Neighboring gene RIKEN cDNA 6330403L08 gene Neighboring gene STARR-seq mESC enhancer starr_14679 Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell projection assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of platelet-derived growth factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF A-chain
    PDGF subunit A
    platelet-derived growth factor A-chain
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363271.1NP_001350200.1  platelet-derived growth factor subunit A isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117698
      Consensus CDS
      CCDS90003.1
      UniProtKB/Swiss-Prot
      P20033
      UniProtKB/TrEMBL
      G5E891, Q7TPH7
      Related
      ENSMUSP00000038870.7, ENSMUST00000046901.14
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
    2. NM_001422136.1NP_001409065.1  platelet-derived growth factor subunit A isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117698
      UniProtKB/Swiss-Prot
      P20033
      UniProtKB/TrEMBL
      G5E891, Q7TPH7
    3. NM_001422139.1NP_001409068.1  platelet-derived growth factor subunit A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117698
      UniProtKB/TrEMBL
      Q7TPH7, Q99L56
      Related
      ENSMUSP00000106521.2, ENSMUST00000110896.2
    4. NM_001422140.1NP_001409069.1  platelet-derived growth factor subunit A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117698
      UniProtKB/TrEMBL
      Q7TPH7, Q99L56
      Related
      ENSMUSP00000106522.2, ENSMUST00000110897.8
    5. NM_008808.4NP_032834.1  platelet-derived growth factor subunit A isoform 1 precursor

      See identical proteins and their annotated locations for NP_032834.1

      Status: VALIDATED

      Source sequence(s)
      AC117698
      Consensus CDS
      CCDS19802.1
      UniProtKB/TrEMBL
      Q7TPH7, Q99L56
      Related
      ENSMUSP00000075463.8, ENSMUST00000076095.14
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region

    RNA

    1. NR_156469.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' exon and lacks the open reading frame found in variant 1.
      Source sequence(s)
      AC117698

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138961761..138986336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240971.4XP_011239273.1  platelet-derived growth factor subunit A isoform X1

      See identical proteins and their annotated locations for XP_011239273.1

      UniProtKB/Swiss-Prot
      P20033
      UniProtKB/TrEMBL
      G5E891, Q7TPH7
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
    2. XM_036164870.1XP_036020763.1  platelet-derived growth factor subunit A isoform X1

      UniProtKB/Swiss-Prot
      P20033
      UniProtKB/TrEMBL
      G5E891, Q7TPH7
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region