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    Hmgxb4 HMG box domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 70823, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hmgxb4provided by MGI
    Official Full Name
    HMG box domain containing 4provided by MGI
    Primary source
    MGI:MGI:1918073
    See related
    Ensembl:ENSMUSG00000034518 AllianceGenome:MGI:1918073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmgb2l1; 4733401K04Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be part of NURF complex. Is expressed in several structures, including aorta; central nervous system; early conceptus; gonad; and thymus. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.5), limb E14.5 (RPKM 8.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hmgxb4 in Genome Data Viewer
    Location:
    8 C1; 8 35.57 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75720305..75758606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (74993650..75031978)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene intestine specific homeobox Neighboring gene STARR-seq mESC enhancer starr_21915 Neighboring gene STARR-seq mESC enhancer starr_21916 Neighboring gene predicted gene, 53440 Neighboring gene STARR-seq mESC enhancer starr_21917 Neighboring gene STARR-positive B cell enhancer ABC_E6664 Neighboring gene STARR-seq mESC enhancer starr_21922 Neighboring gene STARR-seq mESC enhancer starr_21923 Neighboring gene STARR-positive B cell enhancer ABC_E560 Neighboring gene target of myb1 trafficking protein Neighboring gene dpy-30 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. He X, et al. Proc Natl Acad Sci U S A, 2021 Feb 16. PMID 33563757, Free PMC Article
    2. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. Zhou J, et al. J Biol Chem, 2010 Jul 23. PMID 20511232, Free PMC Article
    3. A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo. Wang L, et al. Physiol Rep, 2024 Apr. PMID 38644513, Free PMC Article
    4. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
    5. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo.
      Title: A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo.
    2. Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.
      Title: Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.
    3. the first evidence of this novel HMG2L1 molecule playing an important role in attenuating smooth muscle differentiation
      Title: Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • E430025G12

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HMG domain-containing protein 4
    Names
    high mobility group box 2-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316753.2 → NP_001303682.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL603864
      UniProtKB/TrEMBL
      Q80Y32
      Conserved Domains (2) summary
      cd00084
      Location:291 → 354
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:1 → 123
      DUF4171; Domain of unknown function (DUF4171)

    2. NM_001316754.2 → NP_001303683.1  HMG domain-containing protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon in place of the first five exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL603864
      Consensus CDS
      CCDS85564.1
      UniProtKB/TrEMBL
      Q8BTT5, Q8R579
      Related
      ENSMUSP00000105566.2, ENSMUST00000109940.2
      Conserved Domains (1) summary
      cd00084
      Location:3 → 66
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    3. NM_001415023.1 → NP_001401952.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603864

    4. NM_001415024.1 → NP_001401953.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603864

    5. NM_001415025.1 → NP_001401954.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603864

    6. NM_001415026.1 → NP_001401955.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603864

    7. NM_001415027.1 → NP_001401956.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603864

    8. NM_001415028.1 → NP_001401957.1  HMG domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL603864

    9. NM_178017.3 → NP_821136.1  HMG domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_821136.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL603864
      Consensus CDS
      CCDS22422.1
      UniProtKB/TrEMBL
      Q80Y32
      Related
      ENSMUSP00000045126.8, ENSMUST00000041759.14
      Conserved Domains (2) summary
      cd00084
      Location:400 → 463
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:107 → 225
      DUF4171; Domain of unknown function (DUF4171)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      75720305..75758606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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