Ffar3 free fatty acid receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ffar3provided by MGI
Official Full Name: free fatty acid receptor 3provided by MGI
Primary source: MGI:MGI:2685324
See related: Ensembl:ENSMUSG00000019429 AllianceGenome:MGI:2685324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm478; Gpr41
Summary: Enables G protein-coupled receptor activity. Involved in several processes, including positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and regulation of secretion by cell. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of neuronal action potential; and regulation of heart rate by chemical signal. Is active in membrane. Is expressed in several structures, including adrenal gland; gut; peripheral nerve trunk; spleen; and sympathetic nervous system. Orthologous to several human genes including FFAR3 (free fatty acid receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 1.2), large intestine adult (RPKM 0.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.25 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30553755..30555603, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30854330..30856178, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR41 and GPR43 regulate CD8[+] T cell priming during herpes simplex virus type 1 infection.
Title: GPR41 and GPR43 regulate CD8(+) T cell priming during herpes simplex virus type 1 infection.
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Galphai/o and downstream Smad2/3 and ERK1/2 phosphorylation.
Title: G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gα(i/o) and downstream Smad2/3 and ERK1/2 phosphorylation.
The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.
Title: The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Title: Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.
Title: Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.
FFAR3 is expressed primarily in neurons with a vasoconstrictor phenotype.
Title: Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.
Gpr41 KO mice have hypertension of a vascular origin.
Title: Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.
the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression
Title: Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.
that GPR41 and its ligands, short-chain fatty acids, may play an important role in the fine-tuning of insulin secretion in fed and fasting states
Title: GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2
Title: Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (8) 1 citation

General gene information

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Markers

Ffar3 (e-PCR), detects polymorphism
- UniSTS:534576

NoName (e-PCR)
- UniSTS:490669

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart rate by chemical signal	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: free fatty acid receptor 3

Names: G-protein coupled receptor 41; putative G protein-coupled receptor GPR41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.