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    Nlrp9a NLR family, pyrin domain containing 9A [ Mus musculus (house mouse) ]

    Gene ID: 233001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nlrp9aprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 9Aprovided by MGI
    Primary source
    MGI:MGI:2675292
    See related
    Ensembl:ENSMUSG00000054102 AllianceGenome:MGI:2675292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nalp9a; D7Ertd565e; Nalp-theta
    Summary
    Predicted to enable ATP binding activity. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Nlrp9a in Genome Data Viewer
    Location:
    7 A3; 7 15.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26234448..26273573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26535023..26574148)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18325 Neighboring gene STARR-seq mESC enhancer starr_18326 Neighboring gene NLR family, pyrin domain containing 9C Neighboring gene STARR-seq mESC enhancer starr_18327 Neighboring gene NLR family, pyrin domain containing 4A Neighboring gene STARR-seq mESC enhancer starr_18328 Neighboring gene STARR-seq mESC enhancer starr_18329 Neighboring gene STARR-seq mESC enhancer starr_18330 Neighboring gene STARR-seq mESC enhancer starr_18331 Neighboring gene vomeronasal 1 receptor 185 Neighboring gene STARR-seq mESC enhancer starr_18334 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of Nlrp9a/b/c in mouse preimplantation development. Kanzaki S, et al. Reproduction, 2020 Aug. PMID 32413845
    2. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
    3. Structural, expression, and evolutionary analysis of mouse CIAS1. Anderson JP, et al. Gene, 2004 Aug 18. PMID 15302403, Free PMC Article
    4. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of canonical inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of canonical inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 9A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048219.2 → NP_001041684.1  NACHT, LRR and PYD domains-containing protein 9A isoform 1

      See identical proteins and their annotated locations for NP_001041684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC120367, AK139925, AY364009, DV652646
      Consensus CDS
      CCDS39844.1
      UniProtKB/Swiss-Prot
      Q66X03, Q6UQE7
      UniProtKB/TrEMBL
      D3Z7F5
      Related
      ENSMUSP00000104024.3, ENSMUST00000108387.9
      Conserved Domains (4) summary
      cd00116
      Location:693 → 957
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:9 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:695 → 716
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144 → 303
      NACHT; NACHT domain

    2. NM_001048220.2 → NP_001041685.1  NACHT, LRR and PYD domains-containing protein 9A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC120367, AK139925, AY596202, DV652646
      Consensus CDS
      CCDS39845.1
      UniProtKB/Swiss-Prot
      Q66X03, Q6UQE7
      UniProtKB/TrEMBL
      E9QKM4
      Related
      ENSMUSP00000071685.4, ENSMUST00000071780.10
      Conserved Domains (4) summary
      cd00116
      Location:638 → 902
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:9 → 91
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:640 → 661
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144 → 303
      NACHT; NACHT domain

    3. NM_001302792.1 → NP_001289721.1  NACHT, LRR and PYD domains-containing protein 9A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC120367, AK145355, DV652646
      UniProtKB/Swiss-Prot
      Q66X03, Q6UQE7
      Related
      ENSMUSP00000120498.2, ENSMUST00000153452.8
      Conserved Domains (3) summary
      cd00116
      Location:604 → 868
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:606 → 627
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:55 → 214
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26234448..26273573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194056.1: Suppressed sequence

      Description
      NM_194056.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66X03.1 GenPept UniProtKB/Swiss-Prot:Q66X03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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