Galp galanin-like peptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Galpprovided by MGI
Official Full Name: galanin-like peptideprovided by MGI
Primary source: MGI:MGI:2663979
See related: Ensembl:ENSMUSG00000034660 AllianceGenome:MGI:2663979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable signaling receptor binding activity. Acts upstream of or within behavioral response to starvation and regulation of appetite. Predicted to be located in extracellular region. Is expressed in several structures, including Harderian gland; alimentary system; genitourinary system; immune system; and liver and biliary system. Orthologous to human GALP (galanin like peptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 3.59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (6200089..6219136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (6197090..6216137)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study demonstrates anti-obesity effect of intranasal administration of galanin-like peptide in obese mice
Title: Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice.
we investigated whether PI3K signalling in neurones expressing GALP plays a role in the transcriptional regulation of the GALP gene
Title: Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes.
results indicate the GALP ICV administration can further promote energy metabolism when administered to spontaneously exercising mice
Title: Interactive effect of galanin-like peptide (GALP) and spontaneous exercise on energy metabolism.
Distinct expression of alarin, a splice variant of GALP, in the adult mouse brain demonstrates potential functions in reproduction and metabolism.
Title: Distribution of alarin immunoreactivity in the mouse brain.
GALP induces expression of IL-1 in the brain, and its anorexic and febrile actions are mediated by this cytokine acting via IL-1 type I receptor.
Title: Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide.
GALP may play a role in readjusting energy balance under changing nutritional circumstances
Title: Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide.
hypothalamic GALP gene expression is controlled by leptin signals
Title: Changes in hypothalamic expression levels of galanin-like peptide in rat and mouse models support that it is a leptin-target peptide.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within behavioral response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in modulation of process of another organism	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galanin-like peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.