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    Zfp239 zinc finger protein 239 [ Mus musculus (house mouse) ]

    Gene ID: 22685, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp239provided by MGI
    Official Full Name
    zinc finger protein 239provided by MGI
    Primary source
    MGI:MGI:1306812
    See related
    Ensembl:ENSMUSG00000042097 AllianceGenome:MGI:1306812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mok2; Mok-2; Znf239
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF239 (zinc finger protein 239). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 6.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp239 in Genome Data Viewer
    Location:
    6 F1; 6 55.62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117838907..117849727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117862024..117872766)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 6, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117791080-117791189 Neighboring gene zinc finger protein 637 Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850148-117850426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850781-117850973 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1069 Neighboring gene heterogeneous nuclear ribonucleoprotein F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells. Ernoult-Lange M, et al. Mol Cell Biol, 1990 Jan. PMID 2104662, Free PMC Article
    2. The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse Alu type-2 repetitive elements. Arranz V, et al. Gene, 1994 Nov 18. PMID 7959005
    3. Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins. Ernoult-Lange M, et al. J Mol Evol, 1995 Dec. PMID 8587123
    4. Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains. Arranz V, et al. Mol Cell Biol, 1997 Apr. PMID 9121460, Free PMC Article
    5. Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19. Arranz V, et al. Mamm Genome, 1996 Jan. PMID 8903737

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 239
    Names
    Kruppel zinc finger protein 2
    zinc finger protein MOK-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001792.3 → NP_001001792.1  zinc finger protein 239

      See identical proteins and their annotated locations for NP_001001792.1

      Status: VALIDATED

      Source sequence(s)
      AC153918
      Consensus CDS
      CCDS20466.1
      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Related
      ENSMUSP00000128270.2, ENSMUST00000172088.8
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001360938.2 → NP_001347867.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      Consensus CDS
      CCDS20466.1
      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001410517.1 → NP_001397446.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    4. NM_001410518.1 → NP_001397447.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    5. NM_001410519.1 → NP_001397448.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    6. NM_001410521.1 → NP_001397450.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    7. NM_001410522.1 → NP_001397451.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    8. NM_001410523.1 → NP_001397452.1  zinc finger protein 239

      Status: VALIDATED

      Source sequence(s)
      AC153918
      UniProtKB/Swiss-Prot
      P24399, Q99J71

    9. NM_008616.4 → NP_032642.2  zinc finger protein 239

      See identical proteins and their annotated locations for NP_032642.2

      Status: VALIDATED

      Source sequence(s)
      AC153918
      Consensus CDS
      CCDS20466.1
      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Related
      ENSMUSP00000078374.8, ENSMUST00000079405.15
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_177085.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153918

    2. NR_177086.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153918

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117838907..117849727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255322.2 → XP_030111182.1  zinc finger protein 239 isoform X1

      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030255323.2 → XP_030111183.1  zinc finger protein 239 isoform X1

      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036166030.1 → XP_036021923.1  zinc finger protein 239 isoform X1

      UniProtKB/Swiss-Prot
      P24399, Q99J71
      Conserved Domains (3) summary
      COG5048
      Location:4 → 148
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:114 → 201
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24399.2 GenPept UniProtKB/Swiss-Prot:P24399

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