Mdh2 malate dehydrogenase 2, NAD (mitochondrial) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mdh2provided by MGI
Official Full Name: malate dehydrogenase 2, NAD (mitochondrial)provided by MGI
Primary source: MGI:MGI:97050
See related: Ensembl:ENSMUSG00000019179 AllianceGenome:MGI:97050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDH; Mor1; Mdh-2; Mor-1
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in gluconeogenesis; malate-aspartate shuttle; and tricarboxylic acid cycle. Located in membrane. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 1627.0), heart adult (RPKM 883.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.4 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (135807503..135819240)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135778649..135790386)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis.
Title: Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis.
these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition.
Title: MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
The acetylation of MDH2 was affected by the cellular energy state and subsequently regulated adipogenic differentiation.
Title: Acceleration of adipogenic differentiation via acetylation of malate dehydrogenase 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Wox10 (e-PCR)
- UniSTS:118039

Mor1 (e-PCR), detects polymorphism
- UniSTS:143897

Mor1 (e-PCR), detects polymorphism
- UniSTS:143898

Mdh2 (e-PCR), detects polymorphism
- UniSTS:507061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables L-malate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables L-malate dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables malate dehydrogenase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables malate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADH metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within malate metabolic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in malate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISA Inferred from Sequence Alignment more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: malate dehydrogenase, mitochondrial

Names: mitochondrial malate dehydrogenase 2, NAD

NP_032643.2

EC 1.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008617.2 → NP_032643.2 malate dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_032643.2

Status: PROVISIONAL

Source sequence(s)

BC023482

Consensus CDS

CCDS19746.1

UniProtKB/Swiss-Prot

P08249, Q0QF44, Q8CF79, Q8R1P0

Related

ENSMUSP00000019323.7, ENSMUST00000019323.11

Conserved Domains (2) summary

TIGR01772
Location:26 → 335

MDH_euk_gproteo; malate dehydrogenase, NAD-dependent

cd01337
Location:26 → 334

MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases