Epha10 Eph receptor A10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha10provided by MGI
Official Full Name: Eph receptor A10provided by MGI
Primary source: MGI:MGI:3586824
See related: Ensembl:ENSMUSG00000028876 AllianceGenome:MGI:3586824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A330090H18
Summary: Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be active in dendrite and plasma membrane. Is expressed in central nervous system and metanephros. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human EPHA10 (EPH receptor A10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 7.2), frontal lobe adult (RPKM 6.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.92 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124775408..124811594)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (124881530..124917801)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ephrin A10 is significantly increased in hippocampus following epileptogenesis.
Title: Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

General gene information

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Markers

D4Mit279 (e-PCR), detects polymorphism
- UniSTS:130069

NoName (e-PCR)
- UniSTS:491885

D4Mit147 (e-PCR), detects polymorphism
- UniSTS:129923

21.MMHAP61FRG9.seq (e-PCR)
- UniSTS:123529

34.MMHAP10FRD10.seq (e-PCR)
- UniSTS:124068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin type-A receptor 10

NP_001243361.1

EC 2.7.10.1

NP_808339.2

EC 2.7.10.1

XP_006503090.1

EC 2.7.10.1

XP_006503091.1

EC 2.7.10.1

XP_017175641.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256432.2 → NP_001243361.1 ephrin type-A receptor 10 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL606933

UniProtKB/Swiss-Prot

A2A7J5, Q3UPV5, Q8BYG9

Conserved Domains (7) summary

cd09549
Location:928 → 997

SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors

smart00454
Location:931 → 996

SAM; Sterile alpha motif

cd00063
Location:451 → 551

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07714
Location:644 → 899

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:573 → 639

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cl21453
Location:638 → 902

PKc_like; Protein Kinases, catalytic domain
NM_177671.6 → NP_808339.2 ephrin type-A receptor 10 isoform 2 precursor

See identical proteins and their annotated locations for NP_808339.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK143168

Consensus CDS

CCDS18630.1

UniProtKB/Swiss-Prot

Q8BYG9

Related

ENSMUSP00000050810.6, ENSMUST00000059343.7

Conserved Domains (1) summary

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

124775408..124811594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503027.3 → XP_006503090.1 ephrin type-A receptor 10 isoform X2

Conserved Domains (4) summary

cd00063
Location:465 → 551

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:339 → 431

fn3; Fibronectin type III domain

pfam14575
Location:573 → 639

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_006503028.5 → XP_006503091.1 ephrin type-A receptor 10 isoform X3

Conserved Domains (3) summary

cd00063
Location:465 → 551

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:339 → 431

fn3; Fibronectin type III domain

cl02704
Location:35 → 210

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_017320152.3 → XP_017175641.1 ephrin type-A receptor 10 isoform X1

UniProtKB/TrEMBL

F6WVB0

Related

ENSMUSP00000118801.2, ENSMUST00000149146.2

Conserved Domains (5) summary

cd09549
Location:758 → 827

SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors

cd00063
Location:281 → 381

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam14575
Location:403 → 469

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 40

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cl21453
Location:468 → 732

PKc_like; Protein Kinases, catalytic domain