Syt12 synaptotagmin XII [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt12provided by MGI
Official Full Name: synaptotagmin XIIprovided by MGI
Primary source: MGI:MGI:2159601
See related: Ensembl:ENSMUSG00000049303 AllianceGenome:MGI:2159601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in long-term synaptic potentiation and presynaptic modulation of chemical synaptic transmission. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Colocalizes with synaptic vesicle. Is expressed in adrenal gland and ventral grey horn. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 26.5), genital fat pad adult (RPKM 23.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.07 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4495936..4527171, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4445908..4477143, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptotagmin-12 is essential for cyclic AMP-dependent protein kinase presynaptic long term potentiation at mossy-fiber synapses.
Title: Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB448160 (e-PCR)
- UniSTS:209429

NoName (e-PCR)
- UniSTS:491559

BB348287 (e-PCR)
- UniSTS:209197

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spontaneous exocytosis of neurotransmitter	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
colocalizes_with synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: synaptotagmin-12

Names: sytXII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134164.5 → NP_598925.1 synaptotagmin-12

See identical proteins and their annotated locations for NP_598925.1

Status: VALIDATED

Source sequence(s)

AC124347

Consensus CDS

CCDS29428.1

UniProtKB/Swiss-Prot

Q920N7

UniProtKB/TrEMBL

Q14AG7

Related

ENSMUSP00000055237.4, ENSMUST00000059295.10

Conserved Domains (2) summary

cd08406
Location:284 → 419

C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12

cl14603
Location:152 → 263

C2; C2 domain