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Tnf tumor necrosis factor [ Mus musculus (house mouse) ]

Gene ID: 21926, updated on 27-Nov-2024

Summary

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Official Symbol: Tnfprovided by MGI
Official Full Name: tumor necrosis factorprovided by MGI
Primary source: MGI:MGI:104798
See related: Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

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See Tnf in Genome Data Viewer

Location:: 17 B1; 17 18.59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35418343..35420983, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35199367..35202007, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor necrosis factor alpha induces NOX2-dependent reactive oxygen species production in hypothalamic paraventricular nucleus neurons following angiotensin II infusion.
Title: Tumor necrosis factor alpha induces NOX2-dependent reactive oxygen species production in hypothalamic paraventricular nucleus neurons following angiotensin II infusion.
Tumour necrosis factor alpha regulates the miR-27a-3p-Sfrp1 axis in a mouse model of osteoporosis.
Title: Tumour necrosis factor α regulates the miR-27a-3p-Sfrp1 axis in a mouse model of osteoporosis.
TNF-alpha/Stearate Induced H3K9/18 Histone Acetylation Amplifies IL-6 Expression in 3T3-L1 Mouse Adipocytes.
Title: TNF-α/Stearate Induced H3K9/18 Histone Acetylation Amplifies IL-6 Expression in 3T3-L1 Mouse Adipocytes.
TNF-alpha can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone-invasive pituitary adenoma.
Title: TNF-α can promote membrane invasion by activating the MAPK/MMP9 signaling pathway through autocrine in bone-invasive pituitary adenoma.
Chronic TNF exposure induces glucocorticoid-like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia.
Title: Chronic TNF exposure induces glucocorticoid-like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia.
Microglial TNFalpha controls daily changes in synaptic GABAARs and sleep slow waves.
Title: Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves.
Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFalpha-mediated osteoclastogenesis.
Title: Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFα-mediated osteoclastogenesis.
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-alpha in rheumatoid arthritis.
Title: Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-α in rheumatoid arthritis.
TNFalpha: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease.
Title: TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease.
GSK3beta/NF-kappaB -dependent transcriptional regulation of homeostatic hepatocyte Tnf production.
Title: GSK3β/NF-κB -dependent transcriptional regulation of homeostatic hepatocyte Tnf production.

Submit: New GeneRIF Correction See all GeneRIFs (1676)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (17) 1 citation
Spontaneous (3) 1 citation
Targeted (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnf (e-PCR), detects polymorphism
- UniSTS:144644

Tnf (e-PCR), detects polymorphism
- UniSTS:144645

Tnf (e-PCR), detects polymorphism
- UniSTS:144646

Tnf (e-PCR), detects polymorphism
- UniSTS:144647

Tnf (e-PCR), detects polymorphism
- UniSTS:144648

Tnf (e-PCR), detects polymorphism
- UniSTS:144649

Tnf (e-PCR), detects polymorphism
- UniSTS:144650

Tnf (e-PCR), detects polymorphism
- UniSTS:144651

Tnf (e-PCR), detects polymorphism
- UniSTS:257052

NoName (e-PCR)
- UniSTS:493855

Lta (e-PCR), detects polymorphism
- UniSTS:259368

D20Wox2 (e-PCR)
- UniSTS:118078

Tnf (e-PCR), detects polymorphism
- UniSTS:118078

UniSTS:463959 (e-PCR)
- UniSTS:463959

Tnf (e-PCR), detects polymorphism
- UniSTS:463959

Tnf (e-PCR), detects polymorphism
- UniSTS:525675

Tnf (e-PCR), detects polymorphism
- UniSTS:525960

PMC112151P1 (e-PCR)
- UniSTS:270227

AW824221 (e-PCR)
- UniSTS:209299

D20Wox3 (e-PCR)
- UniSTS:240026

Lta (e-PCR), detects polymorphism
- UniSTS:143795

PMC116546P1 (e-PCR)
- UniSTS:270314

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info	PubMed
enables death receptor agonist activity	IDA Inferred from Direct Assay more info	PubMed
enables death receptor agonist activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular extravasation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chronic inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte migration involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect microglial cell activation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within necroptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bile acid secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of insulin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of action potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood microparticle formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood microparticle formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chronic inflammatory response to antigenic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fever generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fractalkine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fractalkine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-33 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-33 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synoviocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synoviocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of translational initiation by iron	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vitamin D biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vitamin D biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to 3,3',5-triiodo-L-thyronine	IEA Inferred from Electronic Annotation more info
involved_in response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to fructose	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to gold nanoparticle	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to isolation stress	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to macrophage colony-stimulating factor	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in sequestering of triglyceride	IEA Inferred from Electronic Annotation more info
involved_in sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor

Names: cachectin; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278601.1 → NP_001265530.1 tumor necrosis factor isoform 2

See identical proteins and their annotated locations for NP_001265530.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

BY167004, CR974444

Consensus CDS

CCDS70801.1

UniProtKB/TrEMBL

A0A0R4J210, Q3U4I6

Related

ENSMUSP00000126122.2, ENSMUST00000167924.2

Conserved Domains (1) summary

pfam00229
Location:89 → 219

TNF; TNF(Tumour Necrosis Factor) family
NM_013693.3 → NP_038721.1 tumor necrosis factor isoform 1

See identical proteins and their annotated locations for NP_038721.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK153319, AK153800, CR974444

Consensus CDS

CCDS28691.1

UniProtKB/Swiss-Prot

O35853, P06804, Q62326, Q91VF3

UniProtKB/TrEMBL

Q3U4I6, Q3U593

Related

ENSMUSP00000025263.9, ENSMUST00000025263.15

Conserved Domains (1) summary

pfam00229
Location:105 → 235

TNF; TNF(Tumour Necrosis Factor) family