Top3b topoisomerase (DNA) III beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Top3bprovided by MGI
Official Full Name: topoisomerase (DNA) III betaprovided by MGI
Primary source: MGI:MGI:1333803
See related: Ensembl:ENSMUSG00000022779 AllianceGenome:MGI:1333803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within chromosome segregation. Located in condensed chromosome. Is expressed in liver. Orthologous to human TOP3B (DNA topoisomerase III beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 15.8), kidney adult (RPKM 15.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.46 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16688587..16710850)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16870722..16892986)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA topoisomerase Top3beta is impacted by early life stress in the developing female and male rat brain.
Title: DNA topoisomerase Top3β is impacted by early life stress in the developing female and male rat brain.
Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.
Title: Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.
Topoisomerase 3beta knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
Title: Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
This study indicated a role for TOP3beta in mRNA metabolism and suggest that it is involved in neurodevelopmental disorders.
Title: Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.
suggest an unanticipated role for Top3beta beyond DNA repair in the activation of cellular responses to DNA damage
Title: Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
DNA topoisomerase III beta has a role in infertility and aneuploidy
Title: Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta.
Chromosomal abnormalities in top3beta(-/-) mice might lead to a persistent increase in apoptotic cells, which might in turn lead to the progression of autoimmunity
Title: Development of autoimmunity in mice lacking DNA topoisomerase 3beta.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Top3b (e-PCR), detects polymorphism
- UniSTS:259698

NoName (e-PCR)
- UniSTS:237446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA Inferred from Electronic Annotation more info
enables RNA topoisomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA topological change	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA topological change	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA topoisomerase III-beta-TDRD3 complex	ISO Inferred from Sequence Orthology more info
part_of DNA topoisomerase III-beta-TDRD3 complex	NAS Non-traceable Author Statement more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA topoisomerase 3-beta-1

Names: DNA topoisomerase III beta-1; Topo III beta

NP_001313505.1

EC 5.6.2.1

NP_035754.1

EC 5.6.2.1

XP_006522054.1

EC 5.6.2.1

XP_006522055.1

EC 5.6.2.1

XP_006522057.1

EC 5.6.2.1

XP_006522058.1

EC 5.6.2.1

XP_006522060.1

EC 5.6.2.1

XP_017172426.1

EC 5.6.2.1

XP_030104903.1

EC 5.6.2.1

XP_030104904.1

EC 5.6.2.1

XP_030104905.1

EC 5.6.2.1

XP_036015766.1

EC 5.6.2.1

XP_036015767.1

EC 5.6.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326576.1 → NP_001313505.1 DNA topoisomerase 3-beta-1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC166832, AK144709, AW122701

Consensus CDS

CCDS27990.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Related

ENSMUSP00000156132.2, ENSMUST00000232581.2

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
NM_011624.3 → NP_035754.1 DNA topoisomerase 3-beta-1

See identical proteins and their annotated locations for NP_035754.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC166832, AK146475, AW122701, BY035336

Consensus CDS

CCDS27990.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Related

ENSMUSP00000023465.8, ENSMUST00000023465.16

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

16688587..16710850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249043.2 → XP_030104903.1 DNA topoisomerase 3-beta-1 isoform X2

Conserved Domains (2) summary

pfam01131
Location:72 → 485

Topoisom_bac; DNA topoisomerase

cl00718
Location:1 → 70

TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
XM_006521991.5 → XP_006522054.1 DNA topoisomerase 3-beta-1 isoform X1

See identical proteins and their annotated locations for XP_006522054.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_006521997.4 → XP_006522060.1 DNA topoisomerase 3-beta-1 isoform X3

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_006521992.5 → XP_006522055.1 DNA topoisomerase 3-beta-1 isoform X1

See identical proteins and their annotated locations for XP_006522055.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_030249045.2 → XP_030104905.1 DNA topoisomerase 3-beta-1 isoform X2

Conserved Domains (2) summary

pfam01131
Location:72 → 485

Topoisom_bac; DNA topoisomerase

cl00718
Location:1 → 70

TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
XM_030249044.2 → XP_030104904.1 DNA topoisomerase 3-beta-1 isoform X2

Conserved Domains (2) summary

pfam01131
Location:72 → 485

Topoisom_bac; DNA topoisomerase

cl00718
Location:1 → 70

TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
XM_036159873.1 → XP_036015766.1 DNA topoisomerase 3-beta-1 isoform X1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_006521994.4 → XP_006522057.1 DNA topoisomerase 3-beta-1 isoform X1

See identical proteins and their annotated locations for XP_006522057.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_036159874.1 → XP_036015767.1 DNA topoisomerase 3-beta-1 isoform X4

Conserved Domains (1) summary

cd00186
Location:10 → 322

TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
XM_006521995.4 → XP_006522058.1 DNA topoisomerase 3-beta-1 isoform X1

See identical proteins and their annotated locations for XP_006522058.1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase
XM_017316937.3 → XP_017172426.1 DNA topoisomerase 3-beta-1 isoform X1

UniProtKB/Swiss-Prot

Q9Z321

UniProtKB/TrEMBL

Q3UJF5

Conserved Domains (2) summary

cd03362
Location:3 → 167

TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...

pfam01131
Location:169 → 582

Topoisom_bac; DNA topoisomerase