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    Dennd6b DENN domain containing 6B [ Mus musculus (house mouse) ]

    Gene ID: 69440, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dennd6bprovided by MGI
    Official Full Name
    DENN domain containing 6Bprovided by MGI
    Primary source
    MGI:MGI:1916690
    See related
    Ensembl:ENSMUSG00000015377 AllianceGenome:MGI:1916690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam116b; 1700027J05Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 33.8), cerebellum adult (RPKM 32.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd6b in Genome Data Viewer
    Location:
    15 E3; 15 44.7 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89066416..89080793, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89182213..89198427, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1 Neighboring gene microRNA 6959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein DENND6B
    Names
    DENN domain-containing protein 6B
    DENN/MADD domain containing 6B
    family with sequence similarity 116, member B
    protein FAM116B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027081.3 → NP_081357.2  protein DENND6B

      See identical proteins and their annotated locations for NP_081357.2

      Status: VALIDATED

      Source sequence(s)
      AK006427, BB658928, BC058958, BQ444357, BY252285
      Consensus CDS
      CCDS57000.1
      UniProtKB/Swiss-Prot
      B2RSU3, Q9D9V7
      Related
      ENSMUSP00000077978.8, ENSMUST00000078953.9
      Conserved Domains (2) summary
      pfam08616
      Location:250 → 356
      SPA; Stabilization of polarity axis
      cl11519
      Location:151 → 311
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89066416..89080793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248748.1 → XP_030104608.1  protein DENND6B isoform X3

      Conserved Domains (2) summary
      pfam08616
      Location:126 → 232
      SPA; Stabilization of polarity axis
      cl11519
      Location:28 → 187
      DENN; DENN (AEX-3) domain

    2. XM_030248747.2 → XP_030104607.1  protein DENND6B isoform X2

      Conserved Domains (2) summary
      pfam08616
      Location:153 → 259
      SPA; Stabilization of polarity axis
      cl11519
      Location:54 → 214
      DENN; DENN (AEX-3) domain

    3. XM_030248744.2 → XP_030104604.1  protein DENND6B isoform X1

      Conserved Domains (2) summary
      pfam08616
      Location:223 → 329
      SPA; Stabilization of polarity axis
      cl11519
      Location:125 → 284
      DENN; DENN (AEX-3) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9V7.3 GenPept UniProtKB/Swiss-Prot:Q9D9V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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