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    Lratd2 LRAT domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 399603, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lratd2provided by MGI
    Official Full Name
    LRAT domain containing 1provided by MGI
    Primary source
    MGI:MGI:3026924
    See related
    Ensembl:ENSMUSG00000072568 AllianceGenome:MGI:3026924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam84b; D330050I23Rik
    Summary
    Predicted to be located in cytoplasm and plasma membrane. Is expressed in alimentary system; brain; metanephros; submandibular gland primordium; and vibrissa. Orthologous to human LRATD2 (LRAT domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 18.5), ovary adult (RPKM 9.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lratd2 in Genome Data Viewer
    Location:
    15 D1; 15 25.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (60690845..60697954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (60818996..60826105, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23835 Neighboring gene alpha-1-B glycoprotein pseudogene Neighboring gene RIKEN cDNA 9930014A18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11590 Neighboring gene VISTA enhancer mm642 Neighboring gene predicted gene, 53894 Neighboring gene alpha-1-B glycoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. Homer-Bouthiette C, et al. BMC Cancer, 2018 Dec 10. PMID 30526553, Free PMC Article
    2. A genetic analysis of neural progenitor differentiation. Geschwind DH, et al. Neuron, 2001 Feb. PMID 11239426
    3. Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Uslu VV, et al. Nat Genet, 2014 Jul. PMID 24859337
    4. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose Myc as a candidate susceptibility gene, regulated by the gene desert locus, and a potential role for Fam84b in modifying breast cancer development.
      Title: Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein LRATD2
    Names
    family with sequence similarity 84, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162926.1 → NP_001156398.1  protein LRATD2

      Status: VALIDATED

      Source sequence(s)
      AK139928, AK162412, BY426787, CN663980
      Consensus CDS
      CCDS49613.1
      UniProtKB/TrEMBL
      D3YXJ5
      Related
      ENSMUSP00000098200.4, ENSMUST00000100635.5
      Conserved Domains (1) summary
      cl21534
      Location:130 → 212
      NLPC_P60; NlpC/P60 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      60690845..60697954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_384024.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207269.1: Suppressed sequence

      Description
      NM_207269.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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