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    Tada2a transcriptional adaptor 2A [ Mus musculus (house mouse) ]

    Gene ID: 217031, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tada2aprovided by MGI
    Official Full Name
    transcriptional adaptor 2Aprovided by MGI
    Primary source
    MGI:MGI:2144471
    See related
    Ensembl:ENSMUSG00000018651 AllianceGenome:MGI:2144471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tada2l; D030022J10Rik
    Summary
    Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.3), limb E14.5 (RPKM 12.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tada2a in Genome Data Viewer
    Location:
    11 C; 11 51.29 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83969746..84020466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84078920..84129644, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene dual specificity phosphatase 14 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation. Lee JY, et al. Int J Mol Sci, 2021 May 20. PMID 34065515, Free PMC Article
    2. Structure and chromosomal DNA binding of the SWIRM domain. Qian C, et al. Nat Struct Mol Biol, 2005 Dec. PMID 16299514
    3. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
    4. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077
    5. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.
      Title: α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of tubulin deacetylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional adapter 2-alpha
    Names
    ADA2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172562.3 → NP_766150.1  transcriptional adapter 2-alpha

      See identical proteins and their annotated locations for NP_766150.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596447, AL645615
      Consensus CDS
      CCDS25183.1
      UniProtKB/Swiss-Prot
      Q3TZD7, Q8BNK0, Q8CHV6, Q8R3H5
      Related
      ENSMUSP00000018795.7, ENSMUST00000018795.13
      Conserved Domains (4) summary
      COG5114
      Location:11 → 440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      cd00167
      Location:74 → 118
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd02335
      Location:15 → 64
      ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam04433
      Location:374 → 440
      SWIRM; SWIRM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83969746..84020466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532989.5 → XP_006533052.1  transcriptional adapter 2-alpha isoform X1

      Conserved Domains (1) summary
      COG5114
      Location:11 → 420
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    2. XM_030245845.2 → XP_030101705.1  transcriptional adapter 2-alpha isoform X2

      UniProtKB/TrEMBL
      B1AT25
      Conserved Domains (1) summary
      COG5114
      Location:1 → 276
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    3. XM_011248932.4 → XP_011247234.1  transcriptional adapter 2-alpha isoform X3

      Conserved Domains (1) summary
      COG5114
      Location:11 → 272
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RNA

    1. XR_001779958.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHV6.1 GenPept UniProtKB/Swiss-Prot:Q8CHV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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