Amdhd1 amidohydrolase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amdhd1provided by MGI
Official Full Name: amidohydrolase domain containing 1provided by MGI
Primary source: MGI:MGI:1919011
See related: Ensembl:ENSMUSG00000015890 AllianceGenome:MGI:1919011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300019J08Rik
Summary: Predicted to enable imidazolonepropionase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytoplasm. Is expressed in brain; liver; and testis. Orthologous to human AMDHD1 (amidohydrolase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 83.5) and liver E18 (RPKM 10.1) See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 48.54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (93359200..93375973, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (93523338..93540111, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables imidazolonepropionase activity	IBA Inferred from Biological aspect of Ancestor more info
enables imidazolonepropionase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in L-histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable imidazolonepropionase

Names: amidohydrolase domain-containing protein 1

NP_082184.1

EC 3.5.2.7

XP_006514230.1

EC 3.5.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027908.1 → NP_082184.1 probable imidazolonepropionase

See identical proteins and their annotated locations for NP_082184.1

Status: VALIDATED

Source sequence(s)

AK005066, AK090143, BB856590

Consensus CDS

CCDS48671.1

UniProtKB/Swiss-Prot

Q7TPP5, Q811K3, Q8R230, Q9DBA8

Related

ENSMUSP00000016034.3, ENSMUST00000016034.3

Conserved Domains (2) summary

COG1228
Location:4 → 426

HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]

cd01296
Location:43 → 420

Imidazolone-5PH; Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

93359200..93375973 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514167.4 → XP_006514230.1 probable imidazolonepropionase isoform X1

Conserved Domains (1) summary

cl00281
Location:43 → 345

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...