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    Sars2 seryl-aminoacyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

    Gene ID: 71984, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sars2provided by MGI
    Official Full Name
    seryl-aminoacyl-tRNA synthetase 2provided by MGI
    Primary source
    MGI:MGI:1919234
    See related
    Ensembl:ENSMUSG00000070699 AllianceGenome:MGI:1919234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SerRS; SerRSmt; D7Ertd353e; 2410015F05Rik
    Summary
    Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.6), adrenal adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sars2 in Genome Data Viewer
    Location:
    7 B1; 7 16.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28441393..28453304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28741957..28753879)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in seryl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    serine--tRNA ligase, mitochondrial
    Names
    seryl-tRNA synthetase, mitochondrial
    seryl-tRNA(Ser/Sec) synthetase
    NP_076126.2
    XP_006540438.1
    XP_006540439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023637.3NP_076126.2  serine--tRNA ligase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_076126.2

      Status: VALIDATED

      Source sequence(s)
      AK010491, BY649585, CX122368
      Consensus CDS
      CCDS21053.1
      UniProtKB/Swiss-Prot
      Q68FL2, Q9CWP1, Q9JJL8
      Related
      ENSMUSP00000092216.5, ENSMUST00000094632.6
      Conserved Domains (3) summary
      PRK05431
      Location:67493
      PRK05431; seryl-tRNA synthetase; Provisional
      cd00770
      Location:185485
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      cl12057
      Location:67172
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28441393..28453304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540375.5XP_006540438.1  serine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK05431
      Location:67253
      PRK05431; seryl-tRNA synthetase; Provisional
    2. XM_006540376.3XP_006540439.1  serine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00268
      Location:1228
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    RNA

    1. XR_003946566.2 RNA Sequence