Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aticprovided by MGI
Official Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by MGI
Primary source: MGI:MGI:1351352
See related: Ensembl:ENSMUSG00000026192 AllianceGenome:MGI:1351352
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610509C24Rik
Summary: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 26.0), limb E14.5 (RPKM 25.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 36.03 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (71596315..71618562)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (71557156..71579403)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124506 (e-PCR)
- UniSTS:161328

Atic (e-PCR), detects polymorphism
- UniSTS:546663

AW742740 (e-PCR)
- UniSTS:207487

NoName (e-PCR)
- UniSTS:234146

Atic (e-PCR), detects polymorphism
- UniSTS:526034

AW212393 (e-PCR)
- UniSTS:165083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP cyclohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables IMP cyclohydrolase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' AMP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' IMP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in 'de novo' XMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' XMP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in GMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GMP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in brainstem development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in dihydrofolate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dihydrofolate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bifunctional purine biosynthesis protein ATIC

Names: AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein PURH

NP_080471.2

EC 2.1.2.3

EC 3.5.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026195.3 → NP_080471.2 bifunctional purine biosynthesis protein ATIC

See identical proteins and their annotated locations for NP_080471.2

Status: VALIDATED

Source sequence(s)

AK010611, AK012074, CJ178786

Consensus CDS

CCDS15030.1

UniProtKB/Swiss-Prot

Q3UTQ3, Q80UH0, Q8BPF0, Q8BQV9, Q9CRI1, Q9CWJ9, Q9CZW9

Related

ENSMUSP00000027384.6, ENSMUST00000027384.6

Conserved Domains (3) summary

PRK07106
Location:203 → 592

PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional

COG0138
Location:3 → 592

PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]

cd01421
Location:5 → 193

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...