U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Etfbkmt electron transfer flavoprotein beta subunit lysine methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 320204, updated on 27-Nov-2024

    Summary

    Official Symbol
    Etfbkmtprovided by MGI
    Official Full Name
    electron transfer flavoprotein beta subunit lysine methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2443575
    See related
    Ensembl:ENSMUSG00000039958 AllianceGenome:MGI:2443575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mettl20; ETFB-KMT; 4833442J19Rik
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase and peptidyl-lysine trimethylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; respiratory system; and thymus. Orthologous to human ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.6), heart adult (RPKM 5.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Etfbkmt in Genome Data Viewer
    Location:
    6 G3; 6 78.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149042980..149052669)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149141476..149151171)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene STARR-seq mESC enhancer starr_17854 Neighboring gene SEH1-like (S. cerevisiae pseudogene Neighboring gene predicted gene, 23462 Neighboring gene STARR-positive B cell enhancer ABC_E8834 Neighboring gene STARR-seq mESC enhancer starr_17857 Neighboring gene STARR-positive B cell enhancer mm9_chr6:149081472-149081773 Neighboring gene STARR-seq mESC enhancer starr_17859 Neighboring gene STARR-seq mESC enhancer starr_17860 Neighboring gene antagonist of mitotic exit network 1 Neighboring gene STARR-seq mESC enhancer starr_17861 Neighboring gene STARR-seq mESC enhancer starr_17862 Neighboring gene STARR-seq mESC enhancer starr_17863 Neighboring gene STARR-seq mESC enhancer starr_17864 Neighboring gene STARR-seq mESC enhancer starr_17865 Neighboring gene STARR-seq mESC enhancer starr_17866 Neighboring gene STARR-seq mESC enhancer starr_17867 Neighboring gene STARR-seq mESC enhancer starr_17868 Neighboring gene retroelement silencing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    electron transfer flavoprotein beta subunit lysine methyltransferase
    Names
    ETFB lysine methyltransferase
    methyltransferase like 20
    methyltransferase-like protein 20
    protein N-lysine methyltransferase METTL20
    NP_001239023.1
    NP_001239024.1
    NP_001239025.1
    NP_001239026.1
    NP_796075.2
    XP_017177126.1
    XP_030111316.1
    XP_036022115.1
    XP_036022116.1
    XP_036022117.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252094.1NP_001239023.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_001239023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode isoform a.
      Source sequence(s)
      AK132096, BB614316, BC048711, BY081844
      Consensus CDS
      CCDS20715.1
      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Related
      ENSMUSP00000107176.2, ENSMUST00000111551.2
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001252095.1NP_001239024.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_001239024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.
      Source sequence(s)
      BC048711, BY081844, BY135669
      Consensus CDS
      CCDS20715.1
      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001252096.1NP_001239025.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_001239025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.
      Source sequence(s)
      BB614316, BC048711, BY081844, DN174886
      Consensus CDS
      CCDS20715.1
      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Related
      ENSMUSP00000136167.2, ENSMUST00000179873.8
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. NM_001252097.1NP_001239026.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform b

      See identical proteins and their annotated locations for NP_001239026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      BC046911, BY081844
      Consensus CDS
      CCDS85191.1
      UniProtKB/TrEMBL
      Q80VP4
      Related
      ENSMUSP00000144830.2, ENSMUST00000147934.4
      Conserved Domains (1) summary
      cl17173
      Location:3126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. NM_177101.5NP_796075.2  electron transfer flavoprotein beta subunit lysine methyltransferase isoform a

      See identical proteins and their annotated locations for NP_796075.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1, and encodes the longer isoform (a). Variants 1-4 all encode isoform a.
      Source sequence(s)
      BC048711, BY081844
      Consensus CDS
      CCDS20715.1
      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Related
      ENSMUSP00000042102.10, ENSMUST00000047531.16
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      149042980..149052669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166224.1XP_036022117.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

      UniProtKB/TrEMBL
      Q80VP4
      Conserved Domains (1) summary
      cl17173
      Location:3126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_030255456.2XP_030111316.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

      UniProtKB/TrEMBL
      Q80VP4
      Conserved Domains (1) summary
      cl17173
      Location:3126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_036166223.1XP_036022116.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

      UniProtKB/TrEMBL
      E9PY99
      Related
      ENSMUSP00000118701.2, ENSMUST00000134306.8
      Conserved Domains (1) summary
      cl17173
      Location:58158
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_036166222.1XP_036022115.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_017321637.3XP_017177126.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      B8JKU7, Q3V219, Q80ZM3, Q8VEL3
      Conserved Domains (1) summary
      cl17173
      Location:58253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...