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    Ccn3 cellular communication network factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 18133, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccn3provided by MGI
    Official Full Name
    cellular communication network factor 3provided by MGI
    Primary source
    MGI:MGI:109185
    See related
    Ensembl:ENSMUSG00000037362 AllianceGenome:MGI:109185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nov; C130088N23Rik
    Summary
    Enables hormone activity. Involved in several processes, including bone regeneration; negative regulation of insulin secretion; and type B pancreatic cell proliferation. Acts upstream of with a positive effect on negative regulation of SMAD protein signal transduction. Located in extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CCN3 (cellular communication network factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 83.7), frontal lobe adult (RPKM 20.9) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccn3 in Genome Data Viewer
    Location:
    15 D1; 15 21.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54609306..54617158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54745910..54753762)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene mal, T cell differentiation protein 2 Neighboring gene STARR-seq mESC enhancer starr_38689 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 57626

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chondrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chondrocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of monocyte chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCN family member 3
    Names
    nephroblastoma overexpressed
    nephroblastoma-overexpressed gene protein homolog
    novH
    protein NOV homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010930.5NP_035060.1  CCN family member 3 precursor

      See identical proteins and their annotated locations for NP_035060.1

      Status: VALIDATED

      Source sequence(s)
      AC129583
      Consensus CDS
      CCDS27471.1
      UniProtKB/Swiss-Prot
      Q64299, Q8CA67
      UniProtKB/TrEMBL
      Q3U2X7
      Related
      ENSMUSP00000054389.9, ENSMUST00000050027.9
      Conserved Domains (3) summary
      smart00121
      Location:2889
      IB; Insulin growth factor-binding protein homologues
      smart00041
      Location:266335
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:104164
      VWC; von Willebrand factor (vWF) type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      54609306..54617158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)