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    Rbm14 RNA binding motif protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 56275, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbm14provided by MGI
    Official Full Name
    RNA binding motif protein 14provided by MGI
    Primary source
    MGI:MGI:1929092
    See related
    Ensembl:ENSMUSG00000006456 AllianceGenome:MGI:1929092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p16; PSP2; p16K; Sytip; 1300007E16Rik
    Summary
    Enables mRNA binding activity and splicing factor binding activity. Involved in centriole assembly and mRNA splicing, via spliceosome. Acts upstream of or within apoptotic process; gastrulation; and regulation of response to DNA integrity checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; limb; liver; sensory organ; and stomach epithelium. Orthologous to several human genes including RBM14 (RNA binding motif protein 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 59.4), ovary adult (RPKM 56.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rbm14 in Genome Data Viewer
    Location:
    19 A; 19 4.11 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4850594..4861662, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4800566..4811634, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 21992 Neighboring gene STARR-seq mESC enhancer starr_45357 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45358 Neighboring gene RNA binding motif protein 4 Neighboring gene STARR-seq mESC enhancer starr_45361 Neighboring gene STARR-seq mESC enhancer starr_45362 Neighboring gene STARR-seq mESC enhancer starr_45363 Neighboring gene copper chaperone for superoxide dismutase Neighboring gene STARR-positive B cell enhancer ABC_E9452 Neighboring gene coiled-coil domain containing 87

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough Gm21992

    Readthrough gene: Gm21992, Included gene: Rbm4

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables splicing factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein 14
    Names
    synaptotagmin interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019869.3NP_063922.2  RNA-binding protein 14

      See identical proteins and their annotated locations for NP_063922.2

      Status: VALIDATED

      Source sequence(s)
      AK050945, BE956494, BM938190
      Consensus CDS
      CCDS29437.1
      UniProtKB/Swiss-Prot
      Q3TJB6, Q8C2Q3, Q91Z21, Q9DBI6
      UniProtKB/TrEMBL
      Q3U6A2
      Related
      ENSMUSP00000006625.8, ENSMUST00000006625.8
      Conserved Domains (3) summary
      TIGR01628
      Location:3280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12608
      Location:171
      RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
      cd12609
      Location:79146
      RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4850594..4861662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)