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    Apoa4 apolipoprotein A-IV [ Mus musculus (house mouse) ]

    Gene ID: 11808, updated on 9-Dec-2024

    Summary

    Official Symbol
    Apoa4provided by MGI
    Official Full Name
    apolipoprotein A-IVprovided by MGI
    Primary source
    MGI:MGI:88051
    See related
    Ensembl:ENSMUSG00000032080 AllianceGenome:MGI:88051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apoa-4; apo-AIV; apoA-IV
    Summary
    Predicted to enable several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in innate immune response in mucosa and response to stilbenoid. Acts upstream of or within regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 2830.4), small intestine adult (RPKM 1726.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Apoa4 in Genome Data Viewer
    Location:
    9 A5.2; 9 25.36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (46152142..46154756)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (46240844..46243458)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein A-I Neighboring gene apolipoprotein C-III Neighboring gene STARR-seq mESC enhancer starr_24024 Neighboring gene STARR-positive B cell enhancer ABC_E1112 Neighboring gene apolipoprotein A-V Neighboring gene ZPR1 zinc finger

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity  
    enables antioxidant activity  
    enables cholesterol transfer activity  
    enables cholesterol transfer activity  
    enables cholesterol transfer activity  
    enables copper ion binding  
    enables copper ion binding  
    enables identical protein binding  
    enables lipid binding  
    enables phosphatidylcholine binding  
    enables phosphatidylcholine binding  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phospholipid binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in acylglycerol homeostasis  
    involved_in cholesterol efflux  
    involved_in cholesterol efflux  
    involved_in cholesterol efflux  
    involved_in cholesterol homeostasis  
    involved_in cholesterol homeostasis  
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in high-density lipoprotein particle remodeling  
    involved_in high-density lipoprotein particle remodeling  
    involved_in hydrogen peroxide catabolic process  
    involved_in hydrogen peroxide catabolic process  
    involved_in innate immune response in mucosa PubMed 
    involved_in innate immune response in mucosa  
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte cell-cell adhesion  
    involved_in lipid catabolic process  
    involved_in lipid catabolic process  
    involved_in lipid homeostasis  
    involved_in lipid transport  
    involved_in lipoprotein metabolic process  
    involved_in negative regulation of plasma lipoprotein oxidation  
    involved_in negative regulation of plasma lipoprotein oxidation  
    involved_in peripheral nervous system axon regeneration  
    involved_in phosphatidylcholine metabolic process  
    involved_in phosphatidylcholine metabolic process  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in phospholipid efflux  
    involved_in positive regulation of CoA-transferase activity  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of lipoprotein lipase activity  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in protein-lipid complex assembly  
    involved_in protein-lipid complex assembly  
    involved_in regulation of cholesterol transport  
    involved_in regulation of cholesterol transport  
    acts_upstream_of_or_within regulation of intestinal cholesterol absorption PubMed 
    involved_in removal of superoxide radicals  
    involved_in removal of superoxide radicals  
    involved_in response to lipid hydroperoxide  
    involved_in response to lipid hydroperoxide  
    involved_in response to stilbenoid PubMed 
    involved_in response to triglyceride  
    involved_in reverse cholesterol transport  
    involved_in reverse cholesterol transport  
    involved_in very-low-density lipoprotein particle remodeling  
    involved_in very-low-density lipoprotein particle remodeling  
    Items 1 - 25 of 51
    Component Evidence Code Pubs
    located_in cell surface  
    colocalizes_with cell surface  
    part_of chylomicron  
    part_of chylomicron  
    part_of chylomicron  
    located_in cytosol  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular vesicle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle  
    part_of low-density lipoprotein particle  
    located_in synapse  
    is_active_in synapse  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle  

    General protein information

    Preferred Names
    apolipoprotein A-IV
    Names
    apolipoprotein A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007468.2NP_031494.2  apolipoprotein A-IV precursor

      See identical proteins and their annotated locations for NP_031494.2

      Status: VALIDATED

      Source sequence(s)
      AK168687, BF660098
      Consensus CDS
      CCDS23142.1
      UniProtKB/Swiss-Prot
      P06728, Q91XF8
      UniProtKB/TrEMBL
      Q9DBN0
      Related
      ENSMUSP00000034585.7, ENSMUST00000034585.7
      Conserved Domains (2) summary
      pfam01442
      Location:66235
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl21528
      Location:268368
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      46152142..46154756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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