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    SPRY1 sprouty RTK signaling antagonist 1 [ Homo sapiens (human) ]

    Gene ID: 10252, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SPRY1provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 1provided by HGNC
    Primary source
    HGNC:HGNC:11269
    See related
    Ensembl:ENSG00000164056 MIM:602465; AllianceGenome:HGNC:11269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hSPRY1
    Summary
    Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPRY1 in Genome Data Viewer
    Location:
    4q28.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (123396795..123403760)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (126700894..126707854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (124317950..124324915)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900772 Neighboring gene Sharpr-MPRA regulatory region 14026 Neighboring gene uncharacterized LOC124900774 Neighboring gene NANOG hESC enhancer GRCh37_chr4:124271175-124271705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:124272617-124273118 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:124299800-124300518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:124339462-124340019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:124356795-124357294 Neighboring gene VISTA enhancer hs1582 Neighboring gene NANOG hESC enhancer GRCh37_chr4:124422837-124423338 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:124426696-124427543 Neighboring gene tRNA-Cys (anticodon GCA) 2-1 Neighboring gene long intergenic non-protein coding RNA 2435

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women. Jin HS, et al. Mol Genet Metab, 2013 Jan. PMID 23146288
    2. The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells. Masoumi-Moghaddam S, et al. J Ovarian Res, 2014. PMID 24932220, Free PMC Article
    3. Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle. Bigot A, et al. Cell Rep, 2015 Nov 10. PMID 26526994
    4. Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype. He Q, et al. Sci Rep, 2016 Mar 15. PMID 26976794, Free PMC Article
    5. EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma. Cidre-Aranaz F, et al. Oncogene, 2017 Feb 9. PMID 27375017

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms.
      Title: Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms.
    2. Increased SPRY1 expression activates NF-kappaB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
      Title: Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
    3. Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
      Title: Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
    4. Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.
      Title: Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.
    5. Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
      Title: Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
    6. SPRY1 promotes cell proliferation and inhibits apoptosis by activating Hedgehog pathway in acute myeloid leukemia.
      Title: SPRY1 promotes cell proliferation and inhibits apoptosis by activating Hedgehog pathway in acute myeloid leukemia.
    7. Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
      Title: Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
    8. A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.
      Title: A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.
    9. Circ_0020093 ameliorates IL-1beta-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.
      Title: Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.
    10. Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
      Title: Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of sprouty homolog 1 protein (SPRY1, antagonist of FGF signaling) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metanephros development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organ induction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein sprouty homolog 1
    Names
    sprouty homolog 1, antagonist of FGF signaling
    sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
    spry-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258038.2 → NP_001244967.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_001244967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL602431, AY590694, CA447611, DA765300
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
      Related
      ENSP00000498292.1, ENST00000651917.1
      Conserved Domains (1) summary
      pfam05210
      Location:187 → 284
      Sprouty; Sprouty protein (Spry)

    2. NM_001258039.1 → NP_001244968.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_001244968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AV692593, AY590694, CA447611, CN302060
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
      Related
      ENSP00000480540.1, ENST00000622283.1
      Conserved Domains (1) summary
      pfam05210
      Location:187 → 284
      Sprouty; Sprouty protein (Spry)

    3. NM_001375410.1 → NP_001362339.1  protein sprouty homolog 1

      Status: VALIDATED

      Source sequence(s)
      AC026402
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
      Conserved Domains (1) summary
      pfam05210
      Location:187 → 284
      Sprouty; Sprouty protein (Spry)

    4. NM_005841.3 → NP_005832.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_005832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC063856, CA447611
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
      Related
      ENSP00000377871.2, ENST00000394339.2
      Conserved Domains (1) summary
      pfam05210
      Location:187 → 284
      Sprouty; Sprouty protein (Spry)

    5. NM_199327.3 → NP_955359.1  protein sprouty homolog 1

      See identical proteins and their annotated locations for NP_955359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5'UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AL602431, AY192146, AY590694, CA447611
      Consensus CDS
      CCDS3731.1
      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
      Related
      ENSP00000343785.1, ENST00000339241.1
      Conserved Domains (1) summary
      pfam05210
      Location:187 → 284
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      123396795..123403760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449492.1 → XP_047305448.1  protein sprouty homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      126700894..126707854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348720.1 → XP_054204695.1  protein sprouty homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNX6, O43609, Q6PNE0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43609.2 GenPept UniProtKB/Swiss-Prot:O43609

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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