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    IGFBP2 insulin like growth factor binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 3485, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IGFBP2provided by HGNC
    Official Full Name
    insulin like growth factor binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:5471
    See related
    Ensembl:ENSG00000115457 MIM:146731; AllianceGenome:HGNC:5471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IBP2; IGF-BP53
    Summary
    The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in liver (RPKM 67.6), stomach (RPKM 67.2) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IGFBP2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216632828..216664436)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (217115243..217146861)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217497551..217529159)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217485350-217485850 Neighboring gene uncharacterized LOC124907977 Neighboring gene proteasome subunit beta 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217508368-217508942 Neighboring gene uncharacterized LOC124900515 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12306 Neighboring gene IGFBP5 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells. Heinz N, et al. Stem Cells Transl Med, 2015 Sep. PMID 26160960, Free PMC Article
    2. Insulin-like growth factor binding protein 2 promotes glioma development and progression. Dunlap SM, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606927, Free PMC Article
    3. Insulin-like growth factor binding protein-2 regulates β-catenin signaling pathway in glioma cells and contributes to poor patient prognosis. Patil SS, et al. Neuro Oncol, 2016 Nov. PMID 27044294, Free PMC Article
    4. Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. Fukushima T, et al. Anticancer Res, 2007 Nov-Dec. PMID 17970029
    5. Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding. Kuang Z, et al. Biochemistry, 2007 Dec 4. PMID 17985932

    See all (302) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
      Title: Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
    2. A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.
      Title: A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.
    3. IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.
      Title: IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.
    4. Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
      Title: Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
    5. Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.
      Title: Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.
    6. The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
      Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
    7. Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
      Title: Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
    8. Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
      Title: Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
    9. METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
      Title: METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
    10. Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
      Title: Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
    Submit: New GeneRIF Correction See all GeneRIFs (237)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu The gene expression of insulin-like growth factor binding protein 2 (IGFBP2) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IGFBP2 protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor I binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor ligand inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables signaling receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of insulin-like growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 2
    Names
    IGF-binding protein 2
    insulin-like growth factor binding protein 2, 36kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000597.3 → NP_000588.3  insulin-like growth factor-binding protein 2 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC071967, M35410
      Consensus CDS
      CCDS42815.1
      UniProtKB/Swiss-Prot
      P18065, Q14619, Q9UCL3
      Related
      ENSP00000233809.4, ENST00000233809.9
      Conserved Domains (2) summary
      smart00121
      Location:40 → 132
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:227 → 306
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    2. NM_001313990.2 → NP_001300919.1  insulin-like growth factor-binding protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC007563, BC004312, BE735562
      Consensus CDS
      CCDS82570.1
      UniProtKB/TrEMBL
      C9JMY1
      Related
      ENSP00000389646.1, ENST00000456764.1
      Conserved Domains (1) summary
      pfam00086
      Location:83 → 162
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    3. NM_001313992.2 → NP_001300921.1  insulin-like growth factor-binding protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      BC004312, CV810939
      UniProtKB/Swiss-Prot
      P18065
      Conserved Domains (1) summary
      cd00191
      Location:60 → 140
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    4. NM_001313993.2 → NP_001300922.1  insulin-like growth factor-binding protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC073321, BC004312, CN431340
      UniProtKB/Swiss-Prot
      P18065
      Conserved Domains (1) summary
      cd00191
      Location:60 → 140
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      216632828..216664436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      217115243..217146861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18065.2 GenPept UniProtKB/Swiss-Prot:P18065

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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