U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TICAM1 TIR domain containing adaptor molecule 1 [ Homo sapiens (human) ]

    Gene ID: 148022, updated on 27-Nov-2024

    Summary

    Official Symbol
    TICAM1provided by HGNC
    Official Full Name
    TIR domain containing adaptor molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:18348
    See related
    Ensembl:ENSG00000127666 MIM:607601; AllianceGenome:HGNC:18348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
    Summary
    This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in esophagus (RPKM 10.4), duodenum (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TICAM1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4815932..4831712, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4801397..4817189, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4815944..4831724, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4791399-4792056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792057-4792713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792714-4793370 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4804346-4804507 Neighboring gene fem-1 homolog A Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4812531-4813730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9908 Neighboring gene perilipin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4866939-4867439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9909 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4877563-4878446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4878447-4879328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4887083-4888076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4890817-4891318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4891319-4891818 Neighboring gene arrestin domain containing 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4908546-4909452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13788 Neighboring gene ubiquitin like with PHD and ring finger domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Herpes simplex encephalitis, susceptibility to, 4
    MedGen: C3553869 OMIM: 614850 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC35334

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TRIF-dependent toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in TRIF-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in TRIF-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myeloid dendritic cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type I interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to exogenous dsRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in toll-like receptor 3 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ripoptosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TIR domain-containing adapter molecule 1
    Names
    TIR domain containing adaptor inducing interferon-beta
    TIR domain-containing adapter protein inducing IFN-beta
    proline-rich, vinculin and TIR domain-containing protein B
    putative NF-kappa-B-activating protein 502H
    toll like receptor adaptor molecule 1
    toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031998.1 RefSeqGene

      Range
      5001..20819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_358

    mRNA and Protein(s)

    1. NM_001385678.1NP_001372607.1  TIR domain-containing adapter molecule 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (3) summary
      pfam12721
      Location:642683
      RHIM; RIP homotypic interaction motif
      pfam17798
      Location:3134
      TRIF-NTD; TRIF N-terminal domain
      cl23749
      Location:385513
      TIR_2; TIR domain
    2. NM_001385679.1NP_001372608.1  TIR domain-containing adapter molecule 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (3) summary
      pfam12721
      Location:611652
      RHIM; RIP homotypic interaction motif
      pfam17798
      Location:1103
      TRIF-NTD; TRIF N-terminal domain
      cl23749
      Location:354482
      TIR_2; TIR domain
    3. NM_001385680.1NP_001372609.1  TIR domain-containing adapter molecule 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC027319
      Conserved Domains (2) summary
      pfam12721
      Location:446483
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:185313
      TIR_2; TIR domain
    4. NM_182919.4NP_891549.1  TIR domain-containing adapter molecule 1 isoform 1

      See identical proteins and their annotated locations for NP_891549.1

      Status: REVIEWED

      Source sequence(s)
      AB086380, BC035331, BX349282, DR000002
      Consensus CDS
      CCDS12136.1
      UniProtKB/Swiss-Prot
      B3Y691, O75532, Q86XP8, Q8IUC6, Q96GA0
      Related
      ENSP00000248244.4, ENST00000248244.6
      Conserved Domains (2) summary
      pfam12721
      Location:654696
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:399527
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4815932..4831712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4801397..4817189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014261.1: Suppressed sequence

      Description
      NM_014261.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.