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    DAOA-AS1 DAOA antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 282706, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DAOA-AS1provided by HGNC
    Official Full Name
    DAOA antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:30243
    See related
    Ensembl:ENSG00000232307 MIM:607415; AllianceGenome:HGNC:30243
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G30; DAOAAS; DAOA-AS
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See DAOA-AS1 in Genome Data Viewer
    Location:
    13q33.2; 13q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (105459055..105505681, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (104679278..104725943, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (106111404..106158030, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:105760089-105760627 Neighboring gene VISTA enhancer hs1991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7979 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:105926712-105926889 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:105930992-105931492 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:105931493-105931993 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:105934754-105935689 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:105998132-105999331 Neighboring gene VISTA enhancer hs759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:106034184-106034970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:106034971-106035756 Neighboring gene uncharacterized LOC105370344 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_31616 Neighboring gene D-amino acid oxidase activator Neighboring gene uncharacterized LOC105370345 Neighboring gene long intergenic non-protein coding RNA 343 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:106469046-106469979 Neighboring gene uncharacterized LOC124903244

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population. Zou F, et al. Schizophr Res, 2005 Mar 1. PMID 15653269
    2. Family-based association study between G72/G30 genetic polymorphism and schizophrenia. Hong CJ, et al. Neuroreport, 2006 Jul 17. PMID 16791105
    3. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Hattori E, et al. Am J Hum Genet, 2003 May. PMID 12647258, Free PMC Article
    4. Association of G72/G30 with schizophrenia in the Chinese population. Wang X, et al. Biochem Biophys Res Commun, 2004 Jul 9. PMID 15194506
    5. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Korostishevsky M, et al. Biol Psychiatry, 2004 Aug 1. PMID 15271585

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reports G72/G30 expression profiles and behavioral changes in a G72/G30 transgenic mouse model; the transcriptome profile changes and multiple mouse behavioral effects suggest that the G72 gene may play a role in modulating behaviors relevant to psychiatric disorders
      Title: Expression of the G72/G30 gene in transgenic mice induces behavioral changes.
    2. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
      Title: Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.
    3. The transgenic mice which expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to psychiatric disorders.
      Title: Behavioral changes in G72/G30 transgenic mice.
    4. The G72/G30 complex is considered as one of the most promising candidate genes for both schizophrenia and bipolar disorder.
      Title: Further evidence for an association of G72/G30 with schizophrenia in Chinese.
    5. Some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder.
      Title: Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder.
    6. Association of polymorphism with schizophrenia not consistent with those found in other populations, and may be chance findings.
      Title: Association analysis of G72/G30 polymorphisms with schizophrenia in the Korean population.
    7. Results suggest that variability of the DAOA/G30 locus may be involved in the etiology of panic disorder.
      Title: Investigation of the DAOA/G30 locus in panic disorder.
    8. identified statistically significant differences in allele distributions of two markers rs3916965 and rs2391191, and a highly significant association between haplotype AGAC of the G72/G30 locus and schizophrenia in the Chinese population
      Title: Association of G72/G30 with schizophrenia in the Chinese population.
    9. this gene implicated in schizophrenia among Chinese population.
      Title: A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.
    10. data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes
      Title: Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • DAOA antisense RNA 1 (non-protein coding)
    • G30 transcript
    • putative protein LG30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_040247.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AY138548
      Related
      ENST00000448407.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      105459055..105505681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      104679278..104725943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172368.1: Suppressed sequence

      Description
      NM_172368.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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