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    Trmt1 tRNA methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 212528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt1provided by MGI
    Official Full Name
    tRNA methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1289155
    See related
    Ensembl:ENSMUSG00000001909 AllianceGenome:MGI:1289155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720477L24; D8Ertd812e; 6720406L13Rik
    Summary
    Predicted to enable tRNA (guanine(26)-N2)-dimethyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 20.0), testis adult (RPKM 19.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt1 in Genome Data Viewer
    Location:
    8 C3; 8 41.02 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85412953..85426437)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84686324..84699808)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22134 Neighboring gene STARR-positive B cell enhancer ABC_E5025 Neighboring gene STARR-positive B cell enhancer ABC_E883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 26664 Neighboring gene immediate early response 2 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Neighboring gene STARR-positive B cell enhancer ABC_E6667 Neighboring gene STARR-positive B cell enhancer ABC_E5026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87228416-87228525 Neighboring gene lymphoblastomic leukemia 1 Neighboring gene nuclear factor I/X Neighboring gene RIKEN cDNA G430095P16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(26)-N(2))-dimethyltransferase
    Names
    TRM1 tRNA methyltransferase 1 homolog
    n(2),N(2)-dimethylguanosine tRNA methyltransferase
    tRNA 2,2-dimethylguanosine-26 methyltransferase
    tRNA(guanine-26,N(2)-N(2)) methyltransferase
    tRNA(m(2,2)G26)dimethyltransferase
    NP_001158031.1
    NP_001158032.1
    NP_001351104.1
    NP_001351105.1
    NP_932137.2
    XP_006530874.1
    XP_006530875.1
    XP_006530876.1
    XP_006530878.1
    XP_030099261.1
    XP_036009755.1
    XP_036009756.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164559.1 → NP_001158031.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001158031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. This variant encodes isoform 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK159467, BB055133, CN528783
      Consensus CDS
      CCDS40410.2
      UniProtKB/Swiss-Prot
      Q3TBY4, Q3TX08
      UniProtKB/TrEMBL
      A0A0R4IZW7
      Related
      ENSMUSP00000105389.3, ENSMUST00000109767.9
      Conserved Domains (2) summary
      smart00356
      Location:599 → 625
      ZnF_C3H1; zinc finger
      pfam02005
      Location:65 → 499
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    2. NM_001164560.1 → NP_001158032.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses different splice sites in the first two exons which results in the use of an upstream translation start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK159467, BB055133, CN528783
      Consensus CDS
      CCDS52619.1
      UniProtKB/TrEMBL
      E9PWD4, Q3TD26
      Related
      ENSMUSP00000105390.3, ENSMUST00000109768.9
      Conserved Domains (2) summary
      smart00356
      Location:592 → 618
      ZnF_C3H1; zinc finger
      pfam02005
      Location:58 → 492
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    3. NM_001364175.1 → NP_001351104.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK078395, AK159467, BB055133, BB579502, BB841866
      Conserved Domains (2) summary
      smart00356
      Location:339 → 365
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. NM_001364176.1 → NP_001351105.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145556
      UniProtKB/TrEMBL
      Q8R2M8
      Conserved Domains (2) summary
      smart00356
      Location:574 → 600
      ZnF_C3H1; zinc finger
      pfam02005
      Location:40 → 474
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    5. NM_198020.2 → NP_932137.2  tRNA (guanine(26)-N(2))-dimethyltransferase isoform 1

      See identical proteins and their annotated locations for NP_932137.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK159467, BB055133, CN528783
      Consensus CDS
      CCDS40410.2
      UniProtKB/Swiss-Prot
      Q3TBY4, Q3TX08
      UniProtKB/TrEMBL
      A0A0R4IZW7
      Related
      ENSMUSP00000001974.5, ENSMUST00000001974.11
      Conserved Domains (2) summary
      smart00356
      Location:599 → 625
      ZnF_C3H1; zinc finger
      pfam02005
      Location:65 → 499
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85412953..85426437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243401.2 → XP_030099261.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

      Conserved Domains (2) summary
      smart00356
      Location:339 → 365
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006530811.2 → XP_006530874.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

      UniProtKB/TrEMBL
      Q8R2M8
      Conserved Domains (2) summary
      smart00356
      Location:574 → 600
      ZnF_C3H1; zinc finger
      pfam02005
      Location:40 → 474
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    3. XM_006530812.5 → XP_006530875.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006530875.1

      Conserved Domains (2) summary
      smart00356
      Location:408 → 434
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 308
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_036153862.1 → XP_036009755.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

      Conserved Domains (2) summary
      smart00356
      Location:339 → 365
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_006530813.2 → XP_006530876.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006530876.1

      Conserved Domains (2) summary
      smart00356
      Location:408 → 434
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 308
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_036153863.1 → XP_036009756.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

      Conserved Domains (2) summary
      smart00356
      Location:339 → 365
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_006530815.2 → XP_006530878.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X3

      Conserved Domains (2) summary
      smart00356
      Location:339 → 365
      ZnF_C3H1; zinc finger
      cl17173
      Location:1 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_001778420.3 RNA Sequence

    2. XR_004934791.1 RNA Sequence

    3. XR_004934790.1 RNA Sequence

    4. XR_004934792.1 RNA Sequence

    5. XR_001778423.3 RNA Sequence

    6. XR_004934789.1 RNA Sequence

    7. XR_004934793.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TX08.2 GenPept UniProtKB/Swiss-Prot:Q3TX08

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