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    Me3 malic enzyme 3, NADP(+)-dependent, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 109264, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Me3provided by MGI
    Official Full Name
    malic enzyme 3, NADP(+)-dependent, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1916679
    See related
    Ensembl:ENSMUSG00000030621 AllianceGenome:MGI:1916679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700020C08Rik; B230207H15Rik
    Summary
    Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in pyruvate metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 5.3), frontal lobe adult (RPKM 4.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Me3 in Genome Data Viewer
    Location:
    7 D3; 7 50.27 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89281492..89503423)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89632284..89854359)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine protease 23 Neighboring gene STARR-seq mESC enhancer starr_19491 Neighboring gene STARR-seq mESC enhancer starr_19492 Neighboring gene STARR-seq mESC enhancer starr_19493 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53381 Neighboring gene STARR-seq mESC enhancer starr_19494 Neighboring gene predicted gene 15744 Neighboring gene STARR-seq mESC enhancer starr_19496 Neighboring gene coiled-coil domain containing 81 Neighboring gene STARR-positive B cell enhancer ABC_E2241 Neighboring gene heat shock protein nuclear import factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria. Sauer LA, et al. Cancer Res, 1978 Jun. PMID 25711
    2. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    3. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malic enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in malate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent malic enzyme, mitochondrial
    Names
    NADP-ME
    NP_852072.2
    XP_006507252.1
    XP_006507253.1
    XP_006507255.1
    XP_006507257.1
    XP_017177416.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181407.5 → NP_852072.2  NADP-dependent malic enzyme, mitochondrial

      See identical proteins and their annotated locations for NP_852072.2

      Status: VALIDATED

      Source sequence(s)
      AC164643, AC165077
      Consensus CDS
      CCDS21443.1
      UniProtKB/Swiss-Prot
      Q499F4, Q8BMF3
      Related
      ENSMUSP00000032856.7, ENSMUST00000032856.13
      Conserved Domains (1) summary
      PLN03129
      Location:9 → 587
      PLN03129; NADP-dependent malic enzyme; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89281492..89503423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507189.4 → XP_006507252.1  NADP-dependent malic enzyme, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006507252.1

      UniProtKB/Swiss-Prot
      Q499F4, Q8BMF3
      Conserved Domains (1) summary
      PLN03129
      Location:9 → 587
      PLN03129; NADP-dependent malic enzyme; Provisional

    2. XM_017321927.2 → XP_017177416.1  NADP-dependent malic enzyme, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN03129
      Location:9 → 267
      PLN03129; NADP-dependent malic enzyme; Provisional

    3. XM_006507190.5 → XP_006507253.1  NADP-dependent malic enzyme, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006507253.1

      UniProtKB/Swiss-Prot
      Q499F4, Q8BMF3
      Conserved Domains (1) summary
      PLN03129
      Location:9 → 587
      PLN03129; NADP-dependent malic enzyme; Provisional

    4. XM_006507194.5 → XP_006507257.1  NADP-dependent malic enzyme, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN03129
      Location:2 → 318
      PLN03129; NADP-dependent malic enzyme; Provisional

    5. XM_006507192.5 → XP_006507255.1  NADP-dependent malic enzyme, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN03129
      Location:34 → 354
      PLN03129; NADP-dependent malic enzyme; Provisional

    RNA

    1. XR_003946371.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMF3.2 GenPept UniProtKB/Swiss-Prot:Q8BMF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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