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    Hddc3 HD domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hddc3provided by MGI
    Official Full Name
    HD domain containing 3provided by MGI
    Primary source
    MGI:MGI:1915945
    See related
    Ensembl:ENSMUSG00000030532 AllianceGenome:MGI:1915945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MESH1; 1110033O09Rik
    Summary
    Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 7.4), large intestine adult (RPKM 6.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hddc3 in Genome Data Viewer
    Location:
    7 D2; 7 45.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79992864..80000479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80343075..80346716)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RCC1 domain containing 1 Neighboring gene protein regulator of cytokinesis 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions. Huang R, et al. Protein Cell, 2023 Mar 16. PMID 36929003, Free PMC Article
    2. Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory. Kim YJ, et al. Neuron, 2018 Dec 5. PMID 30344048, Free PMC Article
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
    Names
    (ppGpp)ase
    HD domain-containing protein 3
    metazoan SpoT homolog 1
    penta-phosphate guanosine-3'-pyrophosphohydrolase
    NP_001405841.1
    NP_001405842.1
    NP_001405845.1
    NP_001405846.1
    NP_001405847.1
    NP_001405848.1
    NP_001405849.1
    NP_001405850.1
    NP_001405851.1
    NP_081088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418912.1 → NP_001405841.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC136740

    2. NM_001418913.1 → NP_001405842.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC136740

    3. NM_001418916.1 → NP_001405845.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC136740
      UniProtKB/TrEMBL
      A0A0U1RNF0, A0A0U1RNS6
      Related
      ENSMUSP00000145537.2, ENSMUST00000206122.2

    4. NM_001418917.1 → NP_001405846.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC136740
      UniProtKB/TrEMBL
      A0A0U1RNS6

    5. NM_001418918.1 → NP_001405847.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC136740
      UniProtKB/TrEMBL
      A0A0U1RNS6, A0A0U1RQ53
      Related
      ENSMUSP00000146252.2, ENSMUST00000206074.2

    6. NM_001418919.1 → NP_001405848.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC136740

    7. NM_001418920.1 → NP_001405849.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC136740

    8. NM_001418921.1 → NP_001405850.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC136740

    9. NM_001418922.1 → NP_001405851.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC136740
      UniProtKB/TrEMBL
      A0A0U1RNS6
      Related
      ENSMUSP00000145686.2, ENSMUST00000206480.2

    10. NM_026812.3 → NP_081088.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1

      See identical proteins and their annotated locations for NP_081088.1

      Status: VALIDATED

      Source sequence(s)
      AC136740
      Consensus CDS
      CCDS21396.1
      UniProtKB/Swiss-Prot
      Q9D114
      Related
      ENSMUSP00000032747.6, ENSMUST00000032747.7
      Conserved Domains (2) summary
      COG0317
      Location:4 → 130
      SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
      pfam13328
      Location:11 → 135
      HD_4; HD domain

    RNA

    1. NR_184853.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136740

    2. NR_184854.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136740

    3. NR_184855.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136740

    4. NR_184856.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136740

    5. NR_184857.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136740

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79992864..80000479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D114.1 GenPept UniProtKB/Swiss-Prot:Q9D114

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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