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    Nfu1 NFU1 iron-sulfur cluster scaffold [ Mus musculus (house mouse) ]

    Gene ID: 56748, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nfu1provided by MGI
    Official Full Name
    NFU1 iron-sulfur cluster scaffoldprovided by MGI
    Primary source
    MGI:MGI:1913290
    See related
    Ensembl:ENSMUSG00000029993 AllianceGenome:MGI:1913290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-33; Hirip5; 0610006G17Rik
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; genitourinary system; liver; and spleen. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfu1 in Genome Data Viewer
    Location:
    6 D1; 6 37.76 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86986040..87005443)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87009234..87028461)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene STARR-positive B cell enhancer ABC_E6452 Neighboring gene STARR-seq mESC enhancer starr_16547 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87025148-87025378 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene predicted gene, 52909

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins. Lorain S, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342215
    2. The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. Ganesh S, et al. Hum Mol Genet, 2003 Sep 15. PMID 12915448
    3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Names
    HIRA-interacting protein 5
    histone cell cycle regulation defective interacting protein 5
    mHIRIP5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170591.1 → NP_001164062.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001164062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK145558, CD775268
      Consensus CDS
      CCDS51836.1
      UniProtKB/TrEMBL
      A0A0N4SUH8
      Related
      ENSMUSP00000032060.9, ENSMUST00000032060.15
      Conserved Domains (2) summary
      pfam01106
      Location:174 → 240
      NifU; NifU-like domain
      pfam08712
      Location:59 → 146
      Nfu_N; Scaffold protein Nfu/NifU N terminal

    2. NM_020045.3 → NP_064429.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_064429.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK003730, AK145558, CD775268
      Consensus CDS
      CCDS85088.1
      UniProtKB/Swiss-Prot
      Q3ULE0, Q6VNZ7, Q8CF80, Q9D1B7, Q9QZ23
      Related
      ENSMUSP00000113332.3, ENSMUST00000117583.8
      Conserved Domains (2) summary
      pfam01106
      Location:173 → 239
      NifU; NifU-like domain
      pfam08712
      Location:59 → 146
      Nfu_N; Scaffold protein Nfu/NifU N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86986040..87005443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152244.1 → XP_036008137.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

      Conserved Domains (2) summary
      smart00932
      Location:59 → 219
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:247 → 313
      NifU; NifU-like domain

    2. XM_036152245.1 → XP_036008138.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

      Conserved Domains (2) summary
      smart00932
      Location:59 → 219
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:246 → 312
      NifU; NifU-like domain

    3. XM_006506419.2 → XP_006506482.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006506482.1

      UniProtKB/TrEMBL
      A0A0N4SUH8
      Related
      ENSMUSP00000113637.3, ENSMUST00000120240.8
      Conserved Domains (2) summary
      pfam01106
      Location:174 → 240
      NifU; NifU-like domain
      pfam08712
      Location:59 → 146
      Nfu_N; Scaffold protein Nfu/NifU N terminal

    4. XM_006506420.3 → XP_006506483.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_006506483.1

      UniProtKB/Swiss-Prot
      Q3ULE0, Q6VNZ7, Q8CF80, Q9D1B7, Q9QZ23
      Conserved Domains (2) summary
      pfam01106
      Location:173 → 239
      NifU; NifU-like domain
      pfam08712
      Location:59 → 146
      Nfu_N; Scaffold protein Nfu/NifU N terminal

    5. XM_036152246.1 → XP_036008139.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X5

      Conserved Domains (2) summary
      smart00932
      Location:34 → 81
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:109 → 175
      NifU; NifU-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ23.2 GenPept UniProtKB/Swiss-Prot:Q9QZ23

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