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    Mdn1 midasin AAA ATPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 100019, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mdn1provided by MGI
    Official Full Name
    midasin AAA ATPase 1provided by MGI
    Primary source
    MGI:MGI:1926159
    See related
    Ensembl:ENSMUSG00000058006 AllianceGenome:MGI:1926159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm135; D4Abb1e; A130070M06; 4833432B22Rik
    Summary
    Predicted to be involved in ribosomal large subunit assembly and ribosomal large subunit export from nucleus. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleus. Orthologous to human MDN1 (midasin AAA ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.6), testis adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mdn1 in Genome Data Viewer
    Location:
    4 A5; 4 14.3 cM
    Exon count:
    102
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32656867..32775217)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32657114..32775217)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 10 Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene caspase 8 associated protein 2 Neighboring gene predicted gene, 42267 Neighboring gene LYR motif containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Frey BJ, et al. Nat Genet, 2005 Sep. PMID 16127451
    2. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Phelan SA, et al. Genomics, 1998 Nov 15. PMID 9806838
    3. Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Kudo T, et al. Mol Cell Biol, 2004 May. PMID 15121843, Free PMC Article
    4. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346
    5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    midasin
    Names
    MIDAS-containing protein
    midasin homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081392.1 → NP_001074861.1  midasin

      Status: VALIDATED

      Source sequence(s)
      AL805973, AL831774
      Consensus CDS
      CCDS57264.1
      UniProtKB/TrEMBL
      J3QMC5
      Related
      ENSMUSP00000136222.2, ENSMUST00000178134.2
      Conserved Domains (5) summary
      smart00382
      Location:1379 → 1535
      AAA; ATPases associated with a variety of cellular activities
      cd01460
      Location:5309 → 5579
      vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
      pfam07728
      Location:1381 → 1535
      AAA_5; AAA domain (dynein-related subfamily)
      cl21455
      Location:1075 → 1211
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22451
      Location:4679 → 4822
      ASF1_hist_chap; ASF1 like histone chaperone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32656867..32775217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537476.4 → XP_006537539.1  midasin isoform X1

      UniProtKB/TrEMBL
      A2ANY6
      Related
      ENSMUSP00000071569.5, ENSMUST00000071642.11
      Conserved Domains (1) summary
      COG5271
      Location:210 → 2308
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_004941785.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133874.1: Suppressed sequence

      Description
      NM_133874.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    2. NM_177666.2: Suppressed sequence

      Description
      NM_177666.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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