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    Pcdh18 protocadherin 18 [ Mus musculus (house mouse) ]

    Gene ID: 73173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdh18provided by MGI
    Official Full Name
    protocadherin 18provided by MGI
    Primary source
    MGI:MGI:1920423
    See related
    Ensembl:ENSMUSG00000037892 AllianceGenome:MGI:1920423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCDH68L; 3110038E07Rik
    Summary
    Involved in brain development. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human PCDH18 (protocadherin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 26.7), CNS E11.5 (RPKM 14.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcdh18 in Genome Data Viewer
    Location:
    3 C; 3 21.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (49697745..49711723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (49743291..49757383, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07580 Neighboring gene predicted gene, 29741 Neighboring gene predicted gene, 23096 Neighboring gene STARR-seq mESC enhancer starr_07583 Neighboring gene STARR-seq mESC enhancer starr_07584 Neighboring gene STARR-seq mESC enhancer starr_07585 Neighboring gene predicted gene, 40042 Neighboring gene adhesion regulating molecule 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Inhibitory Signaling Receptor Protocadherin-18 Regulates Tumor-Infiltrating CD8(+) T-cell Function. Frey AB. Cancer Immunol Res, 2017 Oct. PMID 28874354
    2. Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells. Vazquez-Cintron EJ, et al. PLoS One, 2012. PMID 22567129, Free PMC Article
    3. Disabled-1 interacts with a novel developmentally regulated protocadherin. Homayouni R, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716507
    4. Cell adhesion molecules expression pattern indicates that somatic cells arbitrate gonadal sex of differentiating bipotential fetal mouse gonad. Piprek RP, et al. Mech Dev, 2017 Oct. PMID 28760667
    5. Maternal diabetes alters transcriptional programs in the developing embryo. Pavlinkova G, et al. BMC Genomics, 2009 Jun 18. PMID 19538749, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protocadherin 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404362.1 → NP_001391291.1  protocadherin 18 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC101940

    2. NM_001404363.1 → NP_001391292.1  protocadherin 18 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC101940

    3. NM_001404364.1 → NP_001391293.1  protocadherin 18 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC101940

    4. NM_001404366.1 → NP_001391295.1  protocadherin 18 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101940
      UniProtKB/TrEMBL
      A0A0A6YXH7

    5. NM_001404367.1 → NP_001391296.1  protocadherin 18 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101940
      UniProtKB/TrEMBL
      A0A0A6YXH7

    6. NM_001404377.1 → NP_001391306.1  protocadherin 18 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101940
      UniProtKB/TrEMBL
      A0A0A6YXH7
      Related
      ENSMUSP00000141995.2, ENSMUST00000191794.2

    7. NM_130448.4 → NP_569715.3  protocadherin 18 isoform 1 precursor

      See identical proteins and their annotated locations for NP_569715.3

      Status: VALIDATED

      Source sequence(s)
      AC101940
      Consensus CDS
      CCDS17334.1
      UniProtKB/Swiss-Prot
      Q69ZG2, Q80VY4, Q8CB88, Q8VHR0
      UniProtKB/TrEMBL
      A0A0A6YXH7
      Related
      ENSMUSP00000039245.8, ENSMUST00000035931.13
      Conserved Domains (2) summary
      cd11304
      Location:470 → 572
      Cadherin_repeat; Cadherin tandem repeat domain
      cl09101
      Location:30 → 111
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      49697745..49711723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHR0.2 GenPept UniProtKB/Swiss-Prot:Q8VHR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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