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    Tjap1 tight junction associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tjap1provided by MGI
    Official Full Name
    tight junction associated protein 1provided by MGI
    Primary source
    MGI:MGI:1921344
    See related
    Ensembl:ENSMUSG00000012296 AllianceGenome:MGI:1921344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pilt; Tjp4; 0610041D19Rik
    Summary
    Acts upstream of or within Golgi organization. Located in endosome; plasma membrane; and trans-Golgi network. Is expressed in tongue muscle and vertebral axis musculature. Orthologous to human TJAP1 (tight junction associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.4), limb E14.5 (RPKM 23.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tjap1 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46568777..46593991, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46257851..46283063, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11645 Neighboring gene Yip1 domain family, member 3 Neighboring gene leucine rich repeat containing 73 Neighboring gene predicted gene, 41588 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene ATP-binding cassette, sub-family C member 10 Neighboring gene STARR-positive B cell enhancer ABC_E1943

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. Kawabe H, et al. J Biol Chem, 2001 Dec 21. PMID 11602598
    2. Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. Tamaki H, et al. FEBS Lett, 2012 Sep 21. PMID 22841714
    3. Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Van Campenhout CA, et al. Dev Cell, 2011 Sep 13. PMID 21920314, Free PMC Article
    4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction-associated protein 1
    Names
    hdlg-binding protein Pilt
    protein incorporated later into tight junctions
    tight junction protein 4 (peripheral)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252473.1 → NP_001239402.1  tight junction-associated protein 1

      See identical proteins and their annotated locations for NP_001239402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC116739
      Consensus CDS
      CCDS28824.1
      UniProtKB/Swiss-Prot
      Q9DCD5
      Related
      ENSMUSP00000153327.2, ENSMUST00000225080.2
      Conserved Domains (2) summary
      COG1196
      Location:17 → 159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:260 → 538
      Pilt; Protein incorporated later into Tight Junctions

    2. NM_001252474.1 → NP_001239403.1  tight junction-associated protein 1

      See identical proteins and their annotated locations for NP_001239403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC116739, AK164925
      Consensus CDS
      CCDS28824.1
      UniProtKB/Swiss-Prot
      Q9DCD5
      Related
      ENSMUSP00000012440.7, ENSMUST00000012440.14
      Conserved Domains (2) summary
      COG1196
      Location:17 → 159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:260 → 538
      Pilt; Protein incorporated later into Tight Junctions

    3. NM_001252475.1 → NP_001239404.1  tight junction-associated protein 1

      See identical proteins and their annotated locations for NP_001239404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC116739
      Consensus CDS
      CCDS28824.1
      UniProtKB/Swiss-Prot
      Q9DCD5
      Related
      ENSMUSP00000137220.2, ENSMUST00000180283.2
      Conserved Domains (2) summary
      COG1196
      Location:17 → 159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:260 → 538
      Pilt; Protein incorporated later into Tight Junctions

    4. NM_028751.3 → NP_083027.1  tight junction-associated protein 1

      See identical proteins and their annotated locations for NP_083027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC116739, AK002882
      Consensus CDS
      CCDS28824.1
      UniProtKB/Swiss-Prot
      Q9DCD5
      Related
      ENSMUSP00000130710.3, ENSMUST00000164342.10
      Conserved Domains (2) summary
      COG1196
      Location:17 → 159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:260 → 538
      Pilt; Protein incorporated later into Tight Junctions

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46568777..46593991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246662.4 → XP_011244964.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244964.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    2. XM_011246667.4 → XP_011244969.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244969.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    3. XM_011246672.4 → XP_011244974.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244974.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    4. XM_011246668.4 → XP_011244970.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244970.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    5. XM_011246670.4 → XP_011244972.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244972.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    6. XM_011246677.4 → XP_011244979.1  tight junction-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011244979.1

      UniProtKB/Swiss-Prot
      Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:260 → 538
      Pilt; Protein incorporated later into Tight Junctions

    7. XM_011246666.4 → XP_011244968.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244968.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    8. XM_011246663.4 → XP_011244965.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244965.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    9. XM_011246665.4 → XP_011244967.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244967.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    10. XM_011246669.4 → XP_011244971.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244971.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    11. XM_011246664.4 → XP_011244966.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244966.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    12. XM_011246674.4 → XP_011244976.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244976.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    13. XM_011246678.3 → XP_011244980.1  tight junction-associated protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011244980.1

      Conserved Domains (1) summary
      pfam15453
      Location:149 → 414
      Pilt; Protein incorporated later into Tight Junctions

    14. XM_011246671.4 → XP_011244973.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244973.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    15. XM_011246673.4 → XP_011244975.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244975.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    16. XM_011246675.4 → XP_011244977.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244977.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Related
      ENSMUSP00000153632.2, ENSMUST00000225413.2
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions

    17. XM_011246676.3 → XP_011244978.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244978.1

      UniProtKB/Swiss-Prot
      I7H459, Q8CFL7, Q8R5I2, Q9DCD5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:283 → 548
      Pilt; Protein incorporated later into Tight Junctions
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCD5.2 GenPept UniProtKB/Swiss-Prot:Q9DCD5

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