Slc39a7 solute carrier family 39 (zinc transporter), member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a7provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 7provided by MGI
Primary source: MGI:MGI:95909
See related: Ensembl:ENSMUSG00000024327 AllianceGenome:MGI:95909
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ke4; Ke-4; Zip7; Ring5; H-2Ke4; H2-Ke4
Summary: Enables zinc ion transmembrane transporter activity. Involved in B cell differentiation; skin epidermis development; and zinc ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 99.5), adrenal adult (RPKM 66.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34247240..34250664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34028266..34031690, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy.
Title: The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy.
we have clarified the functional differences between ZIP7 and ZIP13 and show that their different regulation of cellular zinc homeostasis is critical for dermal development and homeostasis.
Title: Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13 Are Essential for Dermal Development.
Study identified that Zip7 is upregulated by glucose in normal skeletal muscle cells and downregulated in insulin-resistant skeletal muscle. The overexpression of Zip7 in skeletal muscle cells led to the modulation of key genes involved in the insulin signaling axis and glucose metabolism. In vivo mouse model revealed a reduction in Glut4 and Zip7 in the skeletal muscle of mice fed a high-fat diet.
Title: The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet.
Depletion of zinc transporter Zip7 by RNA interference shows reduction of both PI3K/Akt signalling and a significant reduction of multinucleated myofibres and myotubes development. Moreover, we show that mature myofibres, obtained through stimulation with high concentrations of zinc, accumulate zinc and so we hypothesise their function as zinc reservoirs into the cell
Title: Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway.
these findings provide evidence for the importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells. Therapeutic targeting of ZIP7 could lead to effective treatment of gastrointestinal disorders.
Title: Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.
a novel role for Zip7 in glucose metabolism in skeletal muscle
Title: The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells.
Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.
Title: Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI117660 (e-PCR)
- UniSTS:181002

M32010 (e-PCR)
- UniSTS:181010

Slc39a7 (e-PCR), detects polymorphism
- UniSTS:547108

Slc39a7 (e-PCR), detects polymorphism
- UniSTS:463430

RH124680 (e-PCR)
- UniSTS:161502

RH125458 (e-PCR)
- UniSTS:162277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter SLC39A7

Names: H2-K region expressed gene 4; histidine-rich membrane protein Ke4; solute carrier family 39 member 7; zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077709.1 → NP_001071177.1 zinc transporter SLC39A7 precursor

See identical proteins and their annotated locations for NP_001071177.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AA170090, AK159968, AK167344, BY288782

Consensus CDS

CCDS37576.1

UniProtKB/Swiss-Prot

Q31125, Q3TVU6, Q9Z1W1

UniProtKB/TrEMBL

A0A068BIT0, Q14C53

Related

ENSMUSP00000130102.2, ENSMUST00000169397.9

Conserved Domains (1) summary

pfam02535
Location:140 → 453

Zip; ZIP Zinc transporter
NM_008202.2 → NP_032228.2 zinc transporter SLC39A7 precursor

See identical proteins and their annotated locations for NP_032228.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AA170090, AK159968, AK167344, BY288782

Consensus CDS

CCDS37576.1

UniProtKB/Swiss-Prot

Q31125, Q3TVU6, Q9Z1W1

UniProtKB/TrEMBL

A0A068BIT0, Q14C53

Related

ENSMUSP00000025186.9, ENSMUST00000025186.16

Conserved Domains (1) summary

pfam02535
Location:140 → 453

Zip; ZIP Zinc transporter