Fetub fetuin beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fetubprovided by MGI
Official Full Name: fetuin betaprovided by MGI
Primary source: MGI:MGI:1890221
See related: Ensembl:ENSMUSG00000022871 AllianceGenome:MGI:1890221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gugu; D17980; 2310011O17Rik
Summary: Enables metalloendopeptidase inhibitor activity. Involved in binding activity of sperm to zona pellucida and negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including genitourinary system; jaw bone; liver; muscle tissue; and olfactory epithelium. Orthologous to human FETUB (fetuin B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 134.5), liver E18 (RPKM 85.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 13.76 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (22737132..22758518)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (22918382..22939768)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fetuin-B Interacts With Insulin Receptor-beta and Promotes Insulin Resistance in Retina Cells.
Title: Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells.
Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-kappaB Signaling Pathway.
Title: Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway.
Upregulated hepatokine fetuin B aggravates myocardial ischemia/reperfusion injury through inhibiting insulin signaling in diabetic mice.
Title: Upregulated hepatokine fetuin B aggravates myocardial ischemia/reperfusion injury through inhibiting insulin signaling in diabetic mice.
Fetuin-B-deficient female mice are infertile due to an early block to fertilization.
Title: Fetuin-B, a liver-derived plasma protein is essential for fertilization.
Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice.
Title: Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI255764 (e-PCR)
- UniSTS:160541

D17980 (e-PCR)
- UniSTS:124756

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fetuin-B

Names: IRL685; fetuin-like protein IRL685

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083904.1 → NP_001077373.1 fetuin-B isoform 2

See identical proteins and their annotated locations for NP_001077373.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AI255764, AJ242927, BY011532

Consensus CDS

CCDS49799.1

UniProtKB/TrEMBL

Q6YJU1

Related

ENSMUSP00000112324.3, ENSMUST00000116625.10

Conserved Domains (1) summary

pfam00031
Location:77 → 161

Cystatin; Cystatin domain
NM_001083905.1 → NP_001077374.1 fetuin-B isoform 1 precursor

See identical proteins and their annotated locations for NP_001077374.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).

Source sequence(s)

AI255764, AJ242927, AK037043

Consensus CDS

CCDS37300.1

UniProtKB/Swiss-Prot

Q9QXC1

UniProtKB/TrEMBL

Q8CB17

Related

ENSMUSP00000128989.2, ENSMUST00000170805.9

Conserved Domains (2) summary

pfam00031
Location:157 → 241

Cystatin; Cystatin domain

cl09238
Location:34 → 122

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
NM_021564.2 → NP_067539.1 fetuin-B isoform 1 precursor

See identical proteins and their annotated locations for NP_067539.1

Status: VALIDATED

Description

Transcript Variant: This transcript (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).

Source sequence(s)

AI255764, AJ242927, BY011532

Consensus CDS

CCDS37300.1

UniProtKB/Swiss-Prot

Q9QXC1

UniProtKB/TrEMBL

Q8CB17

Related

ENSMUSP00000023587.5, ENSMUST00000023587.12

Conserved Domains (2) summary

pfam00031
Location:157 → 241

Cystatin; Cystatin domain

cl09238
Location:34 → 122

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.