Wbp2 WW domain binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wbp2provided by MGI
Official Full Name: WW domain binding protein 2provided by MGI
Primary source: MGI:MGI:104709
See related: Ensembl:ENSMUSG00000034341 AllianceGenome:MGI:104709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of macromolecule biosynthetic process. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in epidermis and epidermis basal layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to human WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 171.5), duodenum adult (RPKM 125.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.91 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115969397..115977821, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116078571..116086995, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKbeta1.
Title: WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1.
This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk.
Title: Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WW domain-binding protein 2

Names: WBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347642.1 → NP_001334571.1 WW domain-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AI837765, AI844895, AK043037, AL607108, DV657565

Consensus CDS

CCDS83934.1

UniProtKB/Swiss-Prot

P97765

UniProtKB/TrEMBL

Q544A1

Related

ENSMUSP00000102052.4, ENSMUST00000106444.4
NM_001361446.1 → NP_001348375.1 WW domain-binding protein 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon and contains an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant. 1. The encoded isoform (3) has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL607108

Conserved Domains (1) summary

cd13214
Location:30 → 131

PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
NM_016852.3 → NP_058548.1 WW domain-binding protein 2 isoform 1

See identical proteins and their annotated locations for NP_058548.1

Status: VALIDATED

Source sequence(s)

AL607108

Consensus CDS

CCDS25657.1

UniProtKB/Swiss-Prot

A2A860, P97765

UniProtKB/TrEMBL

Q3TRG5, Q544A1

Related

ENSMUSP00000074204.7, ENSMUST00000074628.13

Conserved Domains (1) summary

cd13214
Location:30 → 131

PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain