Itgb4 integrin beta 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb4provided by MGI
Official Full Name: integrin beta 4provided by MGI
Primary source: MGI:MGI:96613
See related: Ensembl:ENSMUSG00000020758 AllianceGenome:MGI:96613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD104; C230078O20
Summary: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon adult (RPKM 42.1), small intestine adult (RPKM 34.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.91 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115865556..115899238)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115974725..116008412)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia.
Title: Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia.
ITGB4 deficiency in airway epithelia enhances HDM-induced airway inflammation through hyperactivation of TLR4 signaling pathway.
Title: ITGB4 deficiency in airway epithelia enhances HDM-induced airway inflammation through hyperactivation of TLR4 signaling pathway.
Airway epithelial ITGB4 deficiency induces airway remodeling in a mouse model.
Title: Airway epithelial ITGB4 deficiency induces airway remodeling in a mouse model.
Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
Title: Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
ITGB4 deficiency induces DNA damage by downregulating HDAC1 in airway epithelial cells under stress stimulation.
Title: ITGB4 deficiency induces DNA damage by downregulating HDAC1 in airway epithelial cells under stress stimulation.
KRAS Mutants Upregulate Integrin beta4 to Promote Invasion and Metastasis in Colorectal Cancer.
Title: KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer.
Integrin-beta4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair.
Title: Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair.
Airway epithelial integrin beta4-deficiency exacerbates lipopolysaccharide-induced acute lung injury.
Title: Airway epithelial integrin β4-deficiency exacerbates lipopolysaccharide-induced acute lung injury.
DNA methylation down-regulates integrin beta4 expression in asthmatic airway epithelial cells.
Title: DNA methylation down-regulates integrin β4 expression in asthmatic airway epithelial cells.
Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response.
Title: Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb4 (e-PCR), detects polymorphism
- UniSTS:143632

RH124554 (e-PCR)
- UniSTS:161376

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
contributes_to insulin-like growth factor I binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to neuregulin binding	ISO Inferred from Sequence Orthology more info
contributes_to neuregulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IEA Inferred from Electronic Annotation more info
involved_in hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination in peripheral nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nail development	IEA Inferred from Electronic Annotation more info
involved_in nail development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system myelin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in skin morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophoblast cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: integrin beta-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005608.3 → NP_001005608.2 integrin beta-4 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL607108, AL645647

Consensus CDS

CCDS36376.1

UniProtKB/TrEMBL

A2A864

Related

ENSMUSP00000127604.2, ENSMUST00000169928.8

Conserved Domains (7) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1508 → 1589

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1622 → 1707

fn3; Fibronectin type III domain

pfam07965
Location:628 → 710

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001405126.1 → NP_001392055.1 integrin beta-4 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AL607108, AL645647

Related

ENSMUSP00000070811.7, ENSMUST00000068981.13
NM_001405127.1 → NP_001392056.1 integrin beta-4 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AL607108, AL645647
NM_133663.3 → NP_598424.2 integrin beta-4 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AL607108, AL645647

Conserved Domains (7) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1458 → 1539

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:547 → 575

EGF_2; EGF-like domain

pfam00041
Location:1572 → 1657

fn3; Fibronectin type III domain

pfam07965
Location:628 → 710

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115865556..115899238

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156446.1 → XP_036012339.1 integrin beta-4 isoform X8

Conserved Domains (6) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1455 → 1536

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1569 → 1654

fn3; Fibronectin type III domain

pfam07965
Location:628 → 710

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017314349.3 → XP_017169838.1 integrin beta-4 isoform X1

Conserved Domains (7) summary

smart00237
Location:992 → 1086

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1577 → 1658

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1691 → 1776

fn3; Fibronectin type III domain

pfam07965
Location:628 → 711

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006532572.5 → XP_006532635.1 integrin beta-4 isoform X4

See identical proteins and their annotated locations for XP_006532635.1

UniProtKB/Swiss-Prot

A2A863, A2A865, A2A866, Q6PCS0, Q8R3J1, Q91W15

Related

ENSMUSP00000102069.2, ENSMUST00000106461.8

Conserved Domains (7) summary

smart00237
Location:992 → 1086

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1524 → 1605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1638 → 1723

fn3; Fibronectin type III domain

pfam07965
Location:628 → 711

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006532573.5 → XP_006532636.1 integrin beta-4 isoform X5

UniProtKB/Swiss-Prot

A2A863

Related

ENSMUSP00000102068.3, ENSMUST00000106460.9

Conserved Domains (7) summary

smart00237
Location:992 → 1086

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1512 → 1593

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1626 → 1711

fn3; Fibronectin type III domain

pfam07965
Location:628 → 711

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017314351.3 → XP_017169840.1 integrin beta-4 isoform X3

Conserved Domains (7) summary

smart00237
Location:992 → 1086

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1574 → 1655

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1688 → 1773

fn3; Fibronectin type III domain

pfam07965
Location:628 → 711

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017314350.3 → XP_017169839.1 integrin beta-4 isoform X2

Conserved Domains (7) summary

smart00237
Location:991 → 1085

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:1576 → 1657

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07974
Location:545 → 575

EGF_2; EGF-like domain

pfam00041
Location:1690 → 1775

fn3; Fibronectin type III domain

pfam07965
Location:628 → 710

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:459 → 487

I-EGF_1; Integrin beta epidermal growth factor like domain 1

cl00057
Location:38 → 455

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_036156447.1 → XP_036012340.1 integrin beta-4 isoform X9

UniProtKB/TrEMBL

Q3UNP2

Conserved Domains (3) summary

smart00237
Location:94 → 188

Calx_beta; Domains in Na-Ca exchangers and integrin-beta4

cd00063
Location:679 → 760

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:793 → 878

fn3; Fibronectin type III domain