Otogl otogelin-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Otoglprovided by MGI
Official Full Name: otogelin-likeprovided by MGI
Primary source: MGI:MGI:3647600
See related: Ensembl:ENSMUSG00000091455 AllianceGenome:MGI:3647600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm6924; EG628870
Summary: Predicted to enable alpha-L-arabinofuranosidase activity. Acts upstream of or within inner ear receptor cell stereocilium organization; protein localization; and vibrational conductance of sound to the inner ear. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in cerebral cortex and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 84B. Orthologous to human OTOGL (otogelin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 2.2), limb E14.5 (RPKM 0.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 56.11 cM

Exon count:: 60

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (107596391..107748240, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (107760530..107912379, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice.
Title: OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice.
Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.
Title: Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548587

NoName (e-PCR)
- UniSTS:548588

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-L-arabinofuranosidase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in L-arabinose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular component organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vibrational conductance of sound to the inner ear	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: otogelin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177567.2 → NP_001171038.1 otogelin-like protein isoform 1 precursor

See identical proteins and their annotated locations for NP_001171038.1

Status: VALIDATED

Source sequence(s)

AC113439, AC123948

Consensus CDS

CCDS56747.1

UniProtKB/Swiss-Prot

D3JEN5, F7A4A7

Related

ENSMUSP00000129467.3, ENSMUST00000165341.5

Conserved Domains (7) summary

smart00216
Location:463 → 625

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:1120 → 1194

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:114 → 260

VWD; von Willebrand factor type D domain

pfam01826
Location:736 → 791

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:669 → 732

C8; C8 domain

cl21545
Location:2252 → 2325

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:1263 → 1350

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
NM_001370989.1 → NP_001357918.1 otogelin-like protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC113439, AC123948

Conserved Domains (7) summary

smart00216
Location:463 → 625

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:1119 → 1193

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:114 → 260

VWD; von Willebrand factor type D domain

pfam01826
Location:736 → 791

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:669 → 732

C8; C8 domain

cl21545
Location:2251 → 2324

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:1262 → 1349

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

107596391..107748240 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314041.2 → XP_017169530.1 otogelin-like protein isoform X2

Conserved Domains (7) summary

smart00216
Location:472 → 634

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:1059 → 1133

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:123 → 269

VWD; von Willebrand factor type D domain

pfam01826
Location:675 → 730

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:321 → 382

C8; C8 domain

cl21545
Location:2191 → 2264

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:1202 → 1289

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
XM_006513929.4 → XP_006513992.1 otogelin-like protein isoform X1

Conserved Domains (7) summary

smart00216
Location:472 → 634

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:1129 → 1203

C8; This domain contains 8 conserved cysteine residues

pfam00094
Location:123 → 269

VWD; von Willebrand factor type D domain

pfam01826
Location:745 → 800

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:678 → 741

C8; C8 domain

cl21545
Location:2248 → 2321

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:1272 → 1359

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
XM_006513931.1 → XP_006513994.1 otogelin-like protein isoform X3

Conserved Domains (6) summary

smart00216
Location:145 → 307

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:802 → 876

C8; This domain contains 8 conserved cysteine residues

pfam01826
Location:418 → 473

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:351 → 414

C8; C8 domain

cl21545
Location:1934 → 2007

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:945 → 1032

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
XM_006513932.2 → XP_006513995.1 otogelin-like protein isoform X4

See identical proteins and their annotated locations for XP_006513995.1

Conserved Domains (6) summary

smart00216
Location:305 → 460

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:495 → 569

C8; This domain contains 8 conserved cysteine residues

pfam01826
Location:111 → 166

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:44 → 107

C8; C8 domain

cl21545
Location:1627 → 1700

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:638 → 725

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
XM_006513933.4 → XP_006513996.1 otogelin-like protein isoform X4

See identical proteins and their annotated locations for XP_006513996.1

Conserved Domains (6) summary

smart00216
Location:305 → 460

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:495 → 569

C8; This domain contains 8 conserved cysteine residues

pfam01826
Location:111 → 166

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:44 → 107

C8; C8 domain

cl21545
Location:1627 → 1700

GHB_like; Glycoprotein hormone beta chain homologues

cl23781
Location:638 → 725

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...