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    Acss3 acyl-CoA synthetase short-chain family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 380660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acss3provided by MGI
    Official Full Name
    acyl-CoA synthetase short-chain family member 3provided by MGI
    Primary source
    MGI:MGI:2685720
    See related
    Ensembl:ENSMUSG00000035948 AllianceGenome:MGI:2685720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm874; 8430416H19Rik
    Summary
    Predicted to enable acetate-CoA ligase activity; medium-chain fatty acid-CoA ligase activity; and propionate-CoA ligase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrion. Is expressed in central nervous system; nose; and respiratory system. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 7.7), subcutaneous fat pad adult (RPKM 6.9) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acss3 in Genome Data Viewer
    Location:
    10 D1; 10 55.66 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (106769375..106959622, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (106933514..107123761, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 Neighboring gene RIKEN cDNA 4930532I03 gene Neighboring gene STARR-seq mESC enhancer starr_27779 Neighboring gene nucleolin pseudogene Neighboring gene STARR-seq mESC enhancer starr_27780 Neighboring gene sulfotransferase family, cytosolic, 1C, member 2 pseudogene Neighboring gene predicted gene, 18040 Neighboring gene PRP38 pre-mRNA processing factor 38 domain containing A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27781 Neighboring gene predicted gene, 24745 Neighboring gene predicted gene, 29674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis. Wang L, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Feb. PMID 37979225
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
      Title: ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables propionate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables propionate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables propionate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA synthetase short-chain family member 3, mitochondrial
    Names
    acetate--CoA ligase 3
    propionate--CoA ligase
    NP_001136276.1
    NP_941038.2
    XP_030101011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142804.2 → NP_001136276.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001136276.1

      Status: VALIDATED

      Source sequence(s)
      AC111014, AC121946, AC134457
      Consensus CDS
      CCDS48688.1
      UniProtKB/Swiss-Prot
      Q14DH7, Q8BZX0
      Related
      ENSMUSP00000128209.2, ENSMUST00000165067.9
      Conserved Domains (1) summary
      cd05967
      Location:57 → 674
      PrpE; Propionyl-CoA synthetase (PrpE)

    2. NM_198636.4 → NP_941038.2  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_941038.2

      Status: VALIDATED

      Source sequence(s)
      AC121946, AC134457
      Consensus CDS
      CCDS24159.1
      UniProtKB/Swiss-Prot
      Q14DH7
      Related
      ENSMUSP00000040823.5, ENSMUST00000044668.5
      Conserved Domains (1) summary
      cl17068
      Location:67 → 482
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      106769375..106959622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245151.1 → XP_030101011.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd05967
      Location:1 → 571
      PrpE; Propionyl-CoA synthetase (PrpE)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14DH7.2 GenPept UniProtKB/Swiss-Prot:Q14DH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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