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    Pald1 phosphatase domain containing, paladin 1 [ Mus musculus (house mouse) ]

    Gene ID: 27355, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pald1provided by MGI
    Official Full Name
    phosphatase domain containing, paladin 1provided by MGI
    Primary source
    MGI:MGI:1351623
    See related
    Ensembl:ENSMUSG00000020092 AllianceGenome:MGI:1351623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pald; MMPAL; mKIAA1274
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; jaw; lung; and urinary system. Orthologous to human PALD1 (phosphatase domain containing paladin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 28.7), ovary adult (RPKM 19.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pald1 in Genome Data Viewer
    Location:
    10 B4; 10 32.19 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61155435..61219325, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61319656..61383546, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A, pseudogene 1 Neighboring gene perforin 1 (pore forming protein) Neighboring gene STARR-seq mESC enhancer starr_26836 Neighboring gene STARR-seq mESC enhancer starr_26839 Neighboring gene STARR-seq mESC enhancer starr_26844 Neighboring gene nodal growth differentiation factor Neighboring gene eukaryotic translation initiation factor 4E binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis. Nitzsche A, et al. EMBO Rep, 2021 Feb 3. PMID 33369848, Free PMC Article
    2. Negative regulators of insulin signaling revealed in a genome-wide functional screen. Huang SM, et al. PLoS One, 2009 Sep 3. PMID 19727444, Free PMC Article
    3. Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema. Egaña I, et al. Sci Rep, 2017 Nov 13. PMID 29133847, Free PMC Article
    4. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Wallgard E, et al. Dev Dyn, 2012 Apr. PMID 22354871
    5. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.
      Title: Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.
    2. Study describes the phenotype of Pald1 +/- and Pald1 -/- mice and characterize lung defects linking Pald1 to sex-specific endothelial cell apoptosis, development of emphysema and chronic obstructive pulmonary disease-like changes in females.
      Title: Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
    3. Paladin, a novel putative phosphatase, displays a dynamic expression pattern in the vasculature; During embryonic stages it is broadly expressed in endothelial cells, while in the adult it is selectively expressed in arterial smooth muscle cells
      Title: Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC169319

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    paladin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372378.1 → NP_001359307.1  paladin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122197, AC151895
      UniProtKB/TrEMBL
      B7ZMW4, B7ZMW5
      Conserved Domains (2) summary
      cd17659
      Location:94 → 386
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cd17660
      Location:480 → 737
      PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

    2. NM_013753.3 → NP_038781.2  paladin isoform 1

      See identical proteins and their annotated locations for NP_038781.2

      Status: VALIDATED

      Source sequence(s)
      AC122197, AC151895
      Consensus CDS
      CCDS23877.1
      UniProtKB/TrEMBL
      A0A0R4J007, B7ZMW5
      Related
      ENSMUSP00000020289.9, ENSMUST00000020289.10
      Conserved Domains (2) summary
      cd17659
      Location:94 → 385
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cd17660
      Location:479 → 736
      PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

    RNA

    1. NR_190530.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122197, AC151895

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61155435..61219325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513706.5 → XP_006513769.1  paladin isoform X1

      See identical proteins and their annotated locations for XP_006513769.1

      UniProtKB/TrEMBL
      B7ZMW4, B7ZMW5
      Conserved Domains (2) summary
      cd17659
      Location:94 → 386
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cd17660
      Location:480 → 737
      PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

    RNA

    1. XR_004936190.1 RNA Sequence

    2. XR_380400.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70261.1 GenPept UniProtKB/Swiss-Prot:P70261

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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