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    Zfc3h1 zinc finger, C3H1-type containing [ Mus musculus (house mouse) ]

    Gene ID: 216345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfc3h1provided by MGI
    Official Full Name
    zinc finger, C3H1-type containingprovided by MGI
    Primary source
    MGI:MGI:2446143
    See related
    Ensembl:ENSMUSG00000034163 AllianceGenome:MGI:2446143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psrc2; Ccdc131
    Summary
    Predicted to be part of exosome (RNase complex). Predicted to be active in nucleus. Orthologous to human ZFC3H1 (zinc finger C3H1-type containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 11.2), CNS E14 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfc3h1 in Genome Data Viewer
    Location:
    10 D2; 10 63.51 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115220691..115268677)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115384799..115432772)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27939 Neighboring gene STARR-seq mESC enhancer starr_27942 Neighboring gene transmembrane protein 19 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene predicted gene, 53633 Neighboring gene leucine rich repeat containing G protein coupled receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr10:114916114-114916415 Neighboring gene STARR-seq mESC enhancer starr_27944 Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger C3H1 domain-containing protein
    Names
    coiled-coil domain containing 131
    proline/serine-rich coiled-coil 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033261.2 → NP_001028433.2  zinc finger C3H1 domain-containing protein

      See identical proteins and their annotated locations for NP_001028433.2

      Status: VALIDATED

      Source sequence(s)
      AK145652, AK172969
      Consensus CDS
      CCDS36062.1
      UniProtKB/TrEMBL
      B2RT41, Q6A049
      Related
      ENSMUSP00000044069.9, ENSMUST00000036044.9
      Conserved Domains (3) summary
      sd00006
      Location:1607 → 1633
      TPR; TPR repeat [structural motif]
      pfam10650
      Location:1189 → 1207
      zf-C3H1; Putative zinc-finger domain
      pfam13414
      Location:1607 → 1670
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      115220691..115268677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513538.5 → XP_006513601.1  zinc finger C3H1 domain-containing protein isoform X1

      UniProtKB/TrEMBL
      Q6A049
      Conserved Domains (5) summary
      TIGR02168
      Location:738 → 1010
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02917
      Location:1354 → 1682
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1608 → 1634
      TPR; TPR repeat [structural motif]
      pfam02463
      Location:201 → 998
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam10650
      Location:1189 → 1209
      zf-C3H1; Putative zinc-finger domain

    2. XM_006513540.5 → XP_006513603.1  zinc finger C3H1 domain-containing protein isoform X3

      UniProtKB/TrEMBL
      Q6A049
      Conserved Domains (5) summary
      TIGR02168
      Location:738 → 1010
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02917
      Location:1354 → 1682
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1608 → 1634
      TPR; TPR repeat [structural motif]
      pfam02463
      Location:201 → 998
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam10650
      Location:1189 → 1209
      zf-C3H1; Putative zinc-finger domain

    3. XM_006513539.5 → XP_006513602.1  zinc finger C3H1 domain-containing protein isoform X2

      UniProtKB/TrEMBL
      Q6A049
      Conserved Domains (5) summary
      TIGR02168
      Location:737 → 1009
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02917
      Location:1353 → 1681
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1607 → 1633
      TPR; TPR repeat [structural motif]
      pfam02463
      Location:201 → 997
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam10650
      Location:1188 → 1208
      zf-C3H1; Putative zinc-finger domain

    4. XM_017313907.3 → XP_017169396.1  zinc finger C3H1 domain-containing protein isoform X5

      UniProtKB/TrEMBL
      Q6P7T8
      Conserved Domains (3) summary
      TIGR02917
      Location:408 → 736
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:662 → 688
      TPR; TPR repeat [structural motif]
      pfam10650
      Location:243 → 263
      zf-C3H1; Putative zinc-finger domain

    5. XM_036155758.1 → XP_036011651.1  zinc finger C3H1 domain-containing protein isoform X4

      UniProtKB/TrEMBL
      Q6P7T8
      Conserved Domains (3) summary
      TIGR02917
      Location:408 → 736
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:662 → 688
      TPR; TPR repeat [structural motif]
      pfam10650
      Location:243 → 262
      zf-C3H1; Putative zinc-finger domain

    RNA

    1. XR_003948675.2 RNA Sequence

    2. XR_003948676.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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