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    Kiss1 KiSS-1 metastasis-suppressor [ Mus musculus (house mouse) ]

    Gene ID: 280287, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kiss1provided by MGI
    Official Full Name
    KiSS-1 metastasis-suppressorprovided by MGI
    Primary source
    MGI:MGI:2663985
    See related
    Ensembl:ENSMUSG00000115958 Ensembl:ENSMUSG00000116158 AllianceGenome:MGI:2663985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kisspeptin; metastatin
    Summary
    Predicted to enable kisspeptin receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; decidualization; and negative regulation of cell migration. Predicted to be located in apical plasma membrane; extracellular space; and neuronal cell body. Is expressed in diencephalon and metanephros. Used to study hypogonadotropic hypogonadism 13 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 7.1), genital fat pad adult (RPKM 4.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kiss1 in Genome Data Viewer
    Location:
    1 E4; 1 57.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133249625..133257460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133321887..133329722)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene predicted gene, 19461 Neighboring gene STARR-seq mESC enhancer starr_02280 Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene Ren1 promoter and enhancer region Neighboring gene STARR-positive B cell enhancer ABC_E11089 Neighboring gene renin 1 structural Neighboring gene ethanolamine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distribution of kisspeptin neurones in the adult female mouse brain. Clarkson J, et al. J Neuroendocrinol, 2009 Aug. PMID 19515163
    2. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. Gill JC, et al. PLoS One, 2010 Jul 30. PMID 20689830, Free PMC Article
    3. Diurnal regulation of hypothalamic kisspeptin is disrupted during mouse pregnancy. Yap CC, et al. J Endocrinol, 2016 Jun. PMID 27068699
    4. Excitability and Burst Generation of AVPV Kisspeptin Neurons Are Regulated by the Estrous Cycle Via Multiple Conductances Modulated by Estradiol Action. Wang L, et al. eNeuro, 2016 May-Jun. PMID 27280155, Free PMC Article
    5. Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Jacobs DC, et al. Endocrinology, 2016 Sep. PMID 27409645

    See all (227) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.
      Title: The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.
    2. Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis.
      Title: Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis.
    3. STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
      Title: STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
    4. Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
      Title: Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
    5. Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.
      Title: Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.
    6. Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
      Title: Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
    7. SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
      Title: SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
    8. Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
      Title: Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
    9. Optogenetic stimulation of Kiss1[ARC] terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice.
      Title: Optogenetic stimulation of Kiss1(ARC) terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice.
    10. Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.
      Title: Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.
    Submit: New GeneRIF Correction See all GeneRIFs (141)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kisspeptin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kisspeptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within decidualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in generation of ovulation cycle rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metastasis-suppressor KiSS-1
    Names
    0610012C01Rik
    Kiss1 metastasis-suppressor
    kisspeptin-1
    metastin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412624.1 → NP_001399553.1  metastasis-suppressor KiSS-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068906
      UniProtKB/TrEMBL
      I0J0X7
      Related
      ENSMUSP00000136746.2, ENSMUST00000178033.5

    2. NM_178260.4 → NP_839991.2  metastasis-suppressor KiSS-1 precursor

      See identical proteins and their annotated locations for NP_839991.2

      Status: VALIDATED

      Source sequence(s)
      AC068906
      Consensus CDS
      CCDS48362.1
      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      UniProtKB/TrEMBL
      I0J0X7
      Related
      ENSMUSP00000142264.2, ENSMUST00000195286.5
      Conserved Domains (1) summary
      pfam15152
      Location:42 → 116
      Kisspeptin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133249625..133257460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529682.2 → XP_006529745.1  metastasis-suppressor KiSS-1 isoform X4

      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      Conserved Domains (1) summary
      pfam15152
      Location:68 → 142
      Kisspeptin

    2. XM_006529681.1 → XP_006529744.1  metastasis-suppressor KiSS-1 isoform X3

      Conserved Domains (1) summary
      pfam15152
      Location:93 → 167
      Kisspeptin

    3. XM_030254793.1 → XP_030110653.1  metastasis-suppressor KiSS-1 isoform X5

      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      UniProtKB/TrEMBL
      I0J0X7
      Conserved Domains (1) summary
      pfam15152
      Location:42 → 116
      Kisspeptin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y4S4.2 GenPept UniProtKB/Swiss-Prot:Q6Y4S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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