Cpa1 carboxypeptidase A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpa1provided by RGD
Official Full Name: carboxypeptidase A1provided by RGD
Primary source: RGD:2388
See related: EnsemblRapid:ENSRNOG00000010725 AllianceGenome:RGD:2388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables exopeptidase activity. Involved in proteolysis involved in protein catabolic process and response to cadmium ion. Predicted to be active in extracellular space. Orthologous to human CPA1 (carboxypeptidase A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 3963.0) and Liver (RPKM 1275.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (60224801..60230928)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (59257417..59263544)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (57952982..57959109)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gene transcripts for CPA1 in mesentery and other extrapancreatic tissues indicate that CPA1 might play a role in the renin-angiotensin system in addition to it'sfunction as digestive enzyme
Title: Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.
Data show that latexin protein expression was reduced after SNI, and the decrease of latexin was associated with an increase of the activity of carboxypeptidase A.
Title: Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
carboxypeptidase A, dipeptidase and Na+/K+ ATPase levels in the rat intestine change when exposed to different doses of cadmium
Title: Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium.

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General gene information

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Markers

Cpa (e-PCR), detects polymorphism
- UniSTS:141388

Cpa1 (e-PCR), detects polymorphism
- UniSTS:468827

RH129113 (e-PCR)
- UniSTS:212421

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables exopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in leukotriene metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxypeptidase A1

Names: carboxypeptidase A1 (pancreatic)

NP_058694.2

EC 3.4.17.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016998.3 → NP_058694.2 carboxypeptidase A1 preproprotein

See identical proteins and their annotated locations for NP_058694.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P00731

UniProtKB/TrEMBL

A6IEH1

Related

ENSRNOP00000014465.1, ENSRNOT00000014465.5

Conserved Domains (2) summary

cd03870
Location:117 → 417

M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup

pfam02244
Location:32 → 100

Propep_M14; Carboxypeptidase activation peptide