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    LINC00922 long intergenic non-protein coding RNA 922 [ Homo sapiens (human) ]

    Gene ID: 283867, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00922provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 922provided by HGNC
    Primary source
    HGNC:HGNC:27545
    See related
    Ensembl:ENSG00000261742 AllianceGenome:HGNC:27545
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lnc-LALC
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00922 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (65284502..65576297, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (71077017..71370608, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (65318405..65610200, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65105573-65106491 Neighboring gene long intergenic non-protein coding RNA 2126 Neighboring gene NANOG hESC enhancer GRCh37_chr16:65260913-65261414 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65263556-65264056 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65264057-65264557 Neighboring gene uncharacterized LOC124903780 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65268706-65269234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65269235-65269763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65269764-65270292 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65340354-65341222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65352533-65353244 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:65408883-65410082 Neighboring gene fragile site, distamycin A type, rare, fra(16)(q22.1) Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:65690017-65690516 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:65691608-65692807 Neighboring gene NANOG hESC enhancer GRCh37_chr16:65747170-65747777 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65761912-65762486 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65794855-65795592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:65800891-65801391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:65802715-65803215 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65805808-65806404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65806405-65806999 Neighboring gene uncharacterized LOC107984823 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65850922-65851531 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:65966974-65968173 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:66008681-66009880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66064029-66064528 Neighboring gene uncharacterized LOC105371316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00922 promotes deterioration of gastric cancer. Ge H, et al. PLoS One, 2022. PMID 35511773, Free PMC Article
    2. Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1. Zhang C, et al. Cell Death Dis, 2021 Feb 26. PMID 33637680, Free PMC Article
    3. LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation. Wang Y, et al. Cell Signal, 2021 Jan. PMID 33045317
    4. LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter. Liao M, et al. Mol Cancer, 2023 Oct 4. PMID 37789393, Free PMC Article
    5. LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5. Ye Z, et al. Mol Cell Biochem, 2021 Oct. PMID 34097192

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter.
      Title: LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter.
    2. LINC00922 promotes deterioration of gastric cancer.
      Title: LINC00922 promotes deterioration of gastric cancer.
    3. LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.
      Title: LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.
    4. Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1.
      Title: Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1.
    5. LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5.
      Title: LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • LZTS1 associated LncRNA in CRC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027755.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009055, AC009062, AC092138
      Related
      ENST00000569736.5

    2. NR_174971.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009055, AC009062, AC092138

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      65284502..65576297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      71077017..71370608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001101346.1: Suppressed sequence

      Description
      NM_001101346.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

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