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    DLX6-AS1 DLX6 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 285987, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DLX6-AS1provided by HGNC
    Official Full Name
    DLX6 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:37151
    See related
    AllianceGenome:HGNC:37151
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Evf-2; DLX6AS; DLX6-AS; NCRNA00212
    Summary
    Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See DLX6-AS1 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (96968515..97014065, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (98198163..98243721, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (96597827..96643377, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene 5K-Del enhancer in SHFM1 region Neighboring gene uncharacterized LOC124901703 Neighboring gene RNA, 7SL, cytoplasmic 252, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96621779-96622304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96622305-96622831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96627585-96628528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:96630843-96631552 Neighboring gene VISTA enhancer hs298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18385 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:96650255-96651454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96653649-96654365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96655292-96655807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26299 Neighboring gene distal-less homeobox 6 Neighboring gene distal-less homeobox 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96727665-96727870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26301 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96763667-96763818 Neighboring gene succinate dehydrogenase complex assembly factor 3 Neighboring gene high mobility group box 3 pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive analysis of dysregulated lncRNAs, miRNAs and mRNAs with associated ceRNA network in esophageal squamous cell carcinoma. Tian W, et al. Gene, 2019 May 15. PMID 30802540
    2. LncRNA DLX6-AS1 increases the expression of HIF-1α and promotes the malignant phenotypes of nasopharyngeal carcinoma cells via targeting MiR-199a-5p. Yang B, et al. Mol Genet Genomic Med, 2020 Jan. PMID 31782911, Free PMC Article
    3. Long noncoding RNA DLX6-AS1 promotes breast cancer progression via miR-505-3p/RUNX2 axis. Zhao P, et al. Eur J Pharmacol, 2019 Dec 15. PMID 31705901
    4. DLX6-AS1 promotes cell proliferation, migration and EMT of gastric cancer through FUS-regulated MAP4K1. Wu Q, et al. Cancer Biol Ther, 2020. PMID 31591939, Free PMC Article
    5. Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury. Tan J, et al. J Bioenerg Biomembr, 2020 Oct. PMID 32666494

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of lncRNA DLX6-AS1 in patients with hepatic carcinoma and its prognostic value.
      Title: Expression of lncRNA DLX6-AS1 in patients with hepatic carcinoma and its prognostic value.
    2. A Peptide Encoded by a Long Non-Coding RNA DLX6-AS1 Facilitates Cell Proliferation, Migration, and Invasion by Activating the wnt/beta-Catenin Signaling Pathway in Non-Small-Cell Lung Cancer Cell.
      Title: A Peptide Encoded by a Long Non-Coding RNA DLX6-AS1 Facilitates Cell Proliferation, Migration, and Invasion by Activating the wnt/β-Catenin Signaling Pathway in Non-Small-Cell Lung Cancer Cell.
    3. cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1.
      Title: cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1.
    4. Silencing long non-coding RNA DLX6-AS1 or restoring microRNA-193b-3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1.
      Title: Silencing long non-coding RNA DLX6-AS1 or restoring microRNA-193b-3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1.
    5. Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis.
      Title: Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis.
    6. DLX6-AS1: a putative lncRNA candidate in multiple human cancers.
      Title: DLX6-AS1: a putative lncRNA candidate in multiple human cancers.
    7. DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis.
      Title: DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis.
    8. Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer.
      Title: Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer.
    9. Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis.
      Title: Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR-513c-5p/PLK4 axis.
    10. DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression.
      Title: DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • DLX6 antisense RNA (non-protein coding)
    • DLX6 antisense RNA 1 (non-protein coding)

    Clone Names

    • FLJ34048

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015448.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004774, AK095619, BE263812

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      96968515..97014065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      98198163..98243721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials