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    CENPO centromere protein O [ Homo sapiens (human) ]

    Gene ID: 79172, updated on 27-Nov-2024

    Summary

    Official Symbol
    CENPOprovided by HGNC
    Official Full Name
    centromere protein Oprovided by HGNC
    Primary source
    HGNC:HGNC:28152
    See related
    Ensembl:ENSG00000138092 MIM:611504; AllianceGenome:HGNC:28152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENP-O; MCM21R; ICEN-36
    Summary
    This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CENPO in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24793425..24822376)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24828225..24857125)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25016294..25045245)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25045379-25045923 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048335-25048894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048895-25049453 Neighboring gene uncharacterized LOC105377626 Neighboring gene Sharpr-MPRA regulatory region 9030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25056543-25057467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25057468-25058391 Neighboring gene adenylate cyclase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25097035-25097779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25121605-25122524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126133-25126634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126635-25127134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11235 Neighboring gene uncharacterized LOC124907742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11238

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC11266

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Mis6-Sim4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of inner kinetochore IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    centromere protein O
    Names
    centromeric protein O
    interphase centromere complex protein 36

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199803.3NP_001186732.1  centromere protein O isoform 2

      See identical proteins and their annotated locations for NP_001186732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC012073, AK027859, BX110829
      Consensus CDS
      CCDS56113.1
      UniProtKB/Swiss-Prot
      Q9BU64
      Related
      ENSP00000417787.1, ENST00000473706.5
      Conserved Domains (1) summary
      pfam09496
      Location:140163
      CENP-O; Cenp-O kinetochore centromere component
    2. NM_001322101.2NP_001309030.1  centromere protein O isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) and variant 1 both encode isoform 1.
      Source sequence(s)
      AC012073, AK027859, BX110829, BX406097, CF993857
      Consensus CDS
      CCDS1714.1
      UniProtKB/Swiss-Prot
      B2RDC0, D6W536, Q53T55, Q96JV3, Q9BU64
      Related
      ENSP00000370214.2, ENST00000380834.7
      Conserved Domains (1) summary
      pfam09496
      Location:146169
      CENP-O; Cenp-O kinetochore centromere component
    3. NM_024322.4NP_077298.1  centromere protein O isoform 1

      See identical proteins and their annotated locations for NP_077298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode isoform 1.
      Source sequence(s)
      AC012073, BC002870, BX110829, CF993857
      Consensus CDS
      CCDS1714.1
      UniProtKB/Swiss-Prot
      B2RDC0, D6W536, Q53T55, Q96JV3, Q9BU64
      Related
      ENSP00000260662.1, ENST00000260662.2
      Conserved Domains (1) summary
      pfam09496
      Location:146169
      CENP-O; Cenp-O kinetochore centromere component

    RNA

    1. NR_136182.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CN263048, CX872478
    2. NR_136183.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CN263048
    3. NR_136184.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CX872478

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24793425..24822376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24828225..24857125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)