Eif1 eukaryotic translation initiation factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif1provided by MGI
Official Full Name: eukaryotic translation initiation factor 1provided by MGI
Primary source: MGI:MGI:105125
See related: Ensembl:ENSMUSG00000035530 AllianceGenome:MGI:105125
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sui1-rs1
Summary: Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. Is expressed in germ cell of testis and testis. Orthologous to human EIF1 (eukaryotic translation initiation factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 117.5), liver E14 (RPKM 95.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100210775..100212925)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100319949..100322099)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-9294 (e-PCR)
- UniSTS:24182

G43274 (e-PCR)
- UniSTS:94916

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of mRNA cis splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic 43S preinitiation complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic 48S preinitiation complex	ISO Inferred from Sequence Orthology more info
part_of multi-eIF complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 1

Names: protein translation factor SUI1 homolog; suppressor of initiator codon mutations, related sequence 1; suppressor of initiator codon mutations-Yeast homolog related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.